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Paper Information

Journal:   IRANIAN JOURNAL OF PUBLIC HEALTH   AUGUST 2014 , Volume 43 , Number SUPPLEMENT 2; Page(s) 27 To 27.
 
Paper: 

PREDICTION OF HA1 PROTEIN LINEAR EPITOPES IN INFLUENZA A VIRUS FOR MAKING VACCINATE

 
 
Author(s):  SONGOL AKRAM*, BEHBAHANI MANDANA, SHARIFI FARIBA, HOSSEINI SADE MOHAMMAD
 
* ISFAHAN UNIVERSITY, ISFAHAN, IRAN
 
Abstract: 

Background: The present study was designed to in silico resolving the major obstacles in the control or in prevention of the diseases caused by avian influenza virus.
Methods: Bioinformatic analysis of influenza virus hemaglutenin large subunit (HA1) was done for specific epitope detection and bioinformatic tools BCPred, Pepito, Disco Tope, Ellipro were used for better understanding and characterizing the HA1 structure and selecting appropriate regions as effective virus epitops.
Results: Prediction of epitope sofewares output were identified protein of extracellular loops effective in surface protein. This result is following with results of experimental test on this protein.
Conclusion: Areas have been identified as a suitable vaccine for colonization and expression in the laboratory. Use of this recombinant vaccine is safe and the contrast of the complete protein lowly induced non especial antibody.

 
Keyword(s): AVIAN INFLUENZA, EPITOPE, HEMAGLUTENIN, BIOINFORMATIC
 
References: 
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