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Paper Information

Journal:   INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM)   SPRING 2013 , Volume 11 , Number 2; Page(s) 107 To 116.
 
Paper: 

GNRH ANALOGUES IN THE PREVENTION OF OVARIAN HYPERSTIMULATION SYNDROME

 
 
Author(s):  ALAMA PILAR, BELLVER JOSE, VIDAL CARMEN, GILES JUAN*
 
* DEPARTMENT OF REPRODUCTION, VALENCIA INFERTILITY INSTITUTE, PLAZA DE LA POLICIA LOCAL 3, VALENCIA 46015, SPAIN
 
Abstract: 

The GnRH analogue (agonist and antagonist GnRH) changed ovarian stimulation. On the one hand, it improved chances of pregnancy to obtain more oocytes and better embryos. This leads to an ovarian hyper-response, which can be complicated by the ovarian hyperstimulation syndrome (OHSS). On the other hand, the GnRH analogue can prevent the incidence of OHSS: GnRH antagonist protocols, GnRH agonist for triggering final oocyte maturation, either together or separately, coasting, and the GnRH analogue may prove useful for avoiding OHSS in high-risk patients. We review these topics in this article.

 
Keyword(s): OVARIAN STIMULATION, OVARIAN HYPERSTIMULATION SYNDROME, PREVENTION, GNRH AGONIST, GNRH ANTAGONIST
 
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