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Paper Information

Journal:   ANESTHESIOLOGY AND PAIN MEDICINE   AUGUST 2014 , Volume 4 , Number 3; Page(s) 0 To 0.
 
Paper: 

EFFECTS OF ANGIOTENSIN CONVERTING ENZYME INHIBITORS BEFORE, DURING AND AFTER CORONARY ARTERY BYPASS GRAFT SURGERY ON HEMODYNAMIC RESPONSES AND VASOACTIVE DRUGS REQUIREMENT

 
 
Author(s):  EBADI AHMAD*, SOLTANZADEH MANSOOR, NESIOONPOUR SHOLEH, AKHONDZADEH REZA, DEHGHANI FIROOZABADI MEHDI, ATTARIYAN MANSOUREH
 
* DEPARTMENT OF CARDIAC ANESTHESIOLOGY, GOLESTAN HOSPITAL, AHVAZ JUNDISHAPUR UNIVERSITY OF MEDICAL SCIENCES, AHVAZ, IRAN
 
Abstract: 

Background: According to the previous studies, antihypertensive drugs should be withdrawn before surgery. Nowadays it is accepted that some drugs effectively control systemic blood pressure (BP) to assure its desirable therapeutic control.
Objectives: In this study, the effects of captopril, an angiotensin converting enzyme inhibitor (ACEI), on hemodynamic changes before, during and after the coronary artery bypass graft (CABG) surgery was studied.
Patients and Methods: In this study, 54 patients were randomly selected in the cardiac surgery ward of Ahvaz Golestan Hospital. Amongst them, 27 patients (control group) did not consume any ACEI for controlling BP but the remained 27 patients (experimental group) used the drugs. In these groups, the effects of captopril on hemodynamic changes before, during and after surgery were studies.
Results: Two groups did not have any significant differences in oxygen saturation (P value: before, 0.15; during, 0.08; and after CABG, 0.53) and pulse rate (P value: before, 0.09; during, 0.25; and after CABG, 0.15). Nevertheless, they had significant differences in changes in systolic and diastolic BP in different time points (P Value of systolic BP: before, 0.001; during, <0.001; and after CABG, 0.007; and P Value of diastolic BP: before, <0.001; during, 0.001; and after CABG, 0.009).
Conclusions: Using ACEI can effectively reduce the systolic and diastolic BP before, during, and after CABG surgery without any effects on oxygen saturation and pulse rate.

 
Keyword(s): CORONARY ARTERY BYPASS, SURGERY, VASODILATOR AGENTS
 
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