Paper Information

Journal:   INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM)   WINTER 2013 , Volume 11 , Number 1; Page(s) 48 To 51.
 
Paper: 

ACUTE MYOCARDIAL INFARCTION SECONDARY TO CATECHOLAMINE RELEASE OWING TO COCAINE ABUSE AND PHEOCHROMOCYTOMA CRISIS

 
 
Author(s):  MARTINEZ QUINTANA EFREN*, JAIMES VIVAS RICARDO, CUBA HERRERA JAVIEL, SAIZ UDAETA BEATRIZ, RODRIGUEZ GONZALEZ FAYNA, MARTINEZ MARTIN MARIA SOLEDAD
 
* CARDIOLOGY DEPARTMENT. HOSPITAL UNIVERSITARIO INSULAR-MOTHER AND CHILD, MARITIME SOUTH AVENUE S/N 35016, LAS PALMAS DE GRAN CANARIA, SPAIN
 
Abstract: 

Most pheochromocytomas are not suspected clinically while a high percentage of them are curable with surgery. We present the case of an adult cocaine-addicted male patient with an underlying pheochromocytoma and repeated myocardial infarctions.
Computed tomography showed a left round adrenal mass, also high 24-hour urine levels of catecholamines and metanephrines were detected from urinalysis. The patient was given alpha and beta blockers, moreover a laparoscopic left adrenalectomy was performed. Cocaine can block the reuptake of noradrenaline, leading to increasing its concentration and consequently its effects as well, and induce local or diffuse coronary vasoconstriction in normal coronary artery segments per se, cocaine can also trigger pheochromocytoma crisis, and therefore, cardiac complications such as myocardial infarction due to these additive effects are intended to occur. For this reason, in the presence of typical clinical manifestations of pheochromocytoma, such as sustained or paroxysmal hypertension, headache, sweating, tachycardia and abdominal pain, probable association of this tumor in patients with cocaine abuse and associated cardiac complications must be ruled out.

 
Keyword(s): PHEOCHROMOCYTOMA, COCAINE, MYOCARDIAL INFARCTION
 
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