Paper Information

Journal:   INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM)   WINTER 2013 , Volume 11 , Number 1; Page(s) 23 To 26.
 
Paper: 

NUMBER OF COMPONENTS OF THE METABOLIC SYNDROME; SMOKING AND INFLAMMATORY MARKERS

 
 
Author(s):  KAWADA TOMOYUKI*, OTSUKA TOSHIAKI, ENDO TOKIOMI, KON YOICHI
 
* DEPARTMENT OF HYGIENE AND PUBLIC HEALTH, NIPPON MEDICAL SCHOOL,1-1-5 SENDAGI, BUNKYO-KU, 113-8602, TOKYO, JAPAN
 
Abstract: 

Background: The association between inflammatory markers and the combination of the smoking status plus a number of components of the metabolic syndrome was not fully evaluated in male Japanese subjects.
Objectives: To demonstrate the association between inflammatory markers and the number of components of the metabolic syndrome by considering smoking status.
Patients and Methods: A total of 3.017 male subjects (1.047 current smokers, 1.970 non-smokers) were included. Metabolic syndrome (MetS) was defined by the criteria of the National Cholesterol Education Program Adult Treatment Panel III. The smoking status was categorized in a binary manner into current smokers or non-smokers.
Results: The geometric mean value of the serum CRP increased linearly as the number of components of MetS increased (P< 0.05). In contrast, the mean values of the total WBC, neutrophil, lymphocyte and monocyte counts showed peak values when the number of MetS components was 3 or 4. The log-transformed serum CRP levels and the WBC counts were significantly correlated with one another (P< 0.001), but Pearson’s correlation coefficient was under 0.3 for current smokers.
Conclusions: Among several inflammatory markers, the serum CRP predominantly changed linearly as the number of MetS increased regardless of smoking status.

 
Keyword(s): METABOLIC SYNDROME, INFLAMMATION, SMOKING
 
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