Paper Information

Journal:   INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM)   WINTER 2013 , Volume 11 , Number 1; Page(s) 3 To 10.
 
Paper: 

SERUM LEPTIN LEVEL IS REDUCED IN NON-OBESE SUBJECTS WITH TYPE 2 DIABETES

 
 
Author(s):  MOHAMMADZADEH GHORBAN*, ZARGHAMI NOSRATOLLAH
 
* HYPERLIPIDEMIA RESEARCH CENTER, DEPARTMENT OF CLINICAL BIOCHEMISTRY, FACULTY OF MEDICINE, AHVAZ JUNDISHAPUR UNIVERSITY OF MEDICAL SCIENCES, AHVAZ, I.R., IRAN
 
Abstract: 

Background: Leptin, a protein released from adipose tissue, could have significant role in pathogenesis of obesity and type 2 diabetes mellitus.
Objectives: This study aimed to evaluate variations in serum leptin levels in non-obese subjects with type 2 diabetes mellitus (T2DM).
Patients and Methods: We studied forty-one patients with type 2 diabetes. Fasting lipid profile, Hemoglobin A1c (HbA1c), serum leptin, insulin, and glucose levels were measured by standard methods.
Results: The serum leptin level in type 2 diabetic patients (19.32±11.43 ng/mL) was significantly lower than that in non-diabetic subjects (32.16±11.02 ng/mL). Serum leptin level was strongly and positively correlated with body mass index (BMI) (r=0.658, P<0.0001) and calculated body fat percentage (r=0.431, P<0.0001) in all the study subjects with a better corrlation in the control subjcts compared to control cases (r=0.661 for BMI and r=0.466 for body fat). On the other hand, leptin showed a positive and significant correlation with insulin and HOMA-
b (homeostasis model assessment for ?-cell function) in both groups. Furthermore, leptin related to homeostasis model assessment for insulin resistance (HOMA-IR) (r=0.422, P=0.006) was observed only in T2DM subjects. Leptin showed negative correlation with waist to hip ratio in diabetic (r=-0.407, P=0.008) and non-diabetic subjects (r=-0.318, P=0.049). In the regression model, BMI, HOMA-?, and gender were independent predictors of leptin in all subjects. However, in non-diabetic and diabetic subjects, ?-cell function and insulin were independent predictors, respectively (P=0.01).
Conclusions: It is speculated that lower serum leptin levels in diabetic patients may be a consequence of male gender. Moreover, results suggest that serum leptin level in women is influenced differently than that in men.

 
Keyword(s): LEPTIN, TYPE 2 DIABETES, BODY MASS INDEX
 
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