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Paper Information

Journal:   IRANIAN JOURNAL OF PUBLIC HEALTH   AUGUST 2014 , Volume 43 , Number SUPPLEMENT 2; Page(s) 23 To 23.
 
Paper: 

IN-SILICO INVESTIGATION OF MIR-222 IN H. PYLORI-ASSOCIATED GASTRIC CANCER

 
 
Author(s):  NOORMOHAMMAD MINA*, KHATAMI MEHRI, TABATABAEIAN HOSEIN, GHAEDI KAMRAN, TALEBI ARDESHIR, HEIDARI MOHAMMAD MEHDI
 
* DEPARTMENT OF BIOLOGY, SCHOOL OF SCIENCES, UNIVERSITY OF YAZD, YAZD, IRAN
 
Abstract: 

Background: Little is known about the potential role of miRNAs in the carcinogenesis of gastric cancer induced by H. pylori. Bioinformatics databases were used to determine possible molecular functions and pathways of miR-222 as a proposed prognostic biomarker in gastric cancer.
Methods: MiR-222 targetome including validated and predicted targets were evaluated by miRTarBase and miRWalk databases. Expression of all miR-222 target genes was analyzed in both normal and tumor gastric cells using UniGene database. Finally, normal and tumor gastric expressing targetome of miR-222 were assessed in DAVID database for enrichment analysis of molecular pathways.
Results: DAVID database outcomes demonstrated that multiple KEGG signaling pathways including pathways in cancer, in gap junction and tight junction and in chemokine signaling pathway are the most engaged pathways induced by miR-222 targetome. Based on the majority of affected signaling pathways, miR-222 may results in progression and elevated invasiveness of gastric cancer by targeting MAPK signaling pathway.
Conclusion: miR-222 correlates with proliferation, apoptosis and cell division through tight junction and MAPK signaling pathways.

 
Keyword(s): GASTRIC CANCER, MICRORNA, HELICOBACTER PYLORI, TARGETOME, SIGNALING PATHWAY
 
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