Paper Information

Journal:   IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)   2014 , Volume 13 , Number 4; Page(s) 1221 To 1226.
 
Paper: 

EFFECT OF A COMBINATION OF OMEPRAZOLE PLUS SUSTAINED RELEASE BACLOFEN VERSUS OMEPRAZOLE ALONE ON SYMPTOMS OF PATIENTS WITH GASTROESOPHAGEAL REFLUX DISEASE (GERD)

 
 
Author(s):  ABBASINAZARI MOHAMMAD*, PANAHI YUNES, MORTAZAVI SEYED ALIREZA, FAHIMI FANAK, VALIZADEGAN GHASEM, MOHTASHAMI REZA, POURHOSEINGHOLI MOHAMMAD AMIN, SHIRVANI BAKHTIARI KAMBIZ
 
* DEPARTMENT OF CLINICAL PHARMACY, SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES, TEHRAN, IRAN
 
Abstract: 

Previous studies have reported the efficacy of baclofen in the treatment of Gastroesophageal Reflux Diseases (GERD). The objective of present study is to evaluatethe effect of co-administration of omeprazole 20 mg/d plus sustained Release baclofen (SR baclofen) vs. omeprazole 20 mg/d plus placebo on alleviation of symptoms in patients with a diagnosis of GERD. A prospective, double blind, placebo controlled trial included 60 patients with diagnosis of GERD have been done. Patients were randomly selected to receive either SR baclofen or a placebo in addition to omeprazole 20 mg/d for a period of 2 weeks. Patients were questioned regarding heartburn, regurgitation, chest pain and hoarseness at the base line and after 2 weeks. All patients tolerated the medications and no patients failed to complete the study due to adverse drug reactions. A total of 53 patients completed the study, 25 in SR baclofen and 28 in placebo group. After 2 weeks, 1 patient (4%) in SR baclofen group reported heartburn and regurgitation. However 13 (46.4%) and 15 (53.6%) of patients in the placebo group had heartburn and regurgitation respectively. The analysis of the data shows that there is a significant difference between the two groups in heartburn and regurgitation (p<0.0001, p<0.0001 respectively). Statistical analysis revealed a significant difference in two groups regarding total GERD score (p<0.0001). The results of the present study suggest that a combination of SR baclofen and omeprazole may be a more effective treatment for heartburn and regurgitation than omeprazole alone.

 
Keyword(s): BACLOFEN, OMEPRAZOLE, GERD, SUSTAINED RELEASE
 
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