Paper Information

Journal:   IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)   2014 , Volume 13 , Number 4; Page(s) 1295 To 1301.
 
Paper: 

EFFECT OF DIETARY ETHANOLIC EXTRACT OF LAVANDULA OFFICINALIS ON SERUM LIPIDS PROFILE IN RATS

 
 
Author(s):  RABIEI ZAHRA, RAFIEIAN KOPAEI MAHMOUD*, MOKHTARI SHIVA, SHAHRANI MEHRDAD
 
* MEDICAL PLANTS RESEARCH CENTER, SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES, SHAHREKORD, IRAN
 
Abstract: 

Antioxidants are effective in prevention and treatment of cardiovascular diseases. Lavandula officinalis possesses antioxidant activity, therefore, in this study; the effects of Lavandula officinalis extract were investigated on serum lipids levels of rats. Experimental mature male Wistar rats were treated with 100, 200 or 400 mg/Kg/day of lavender ethanolic extract or distilled water for 25 days via gastric gavage (n=8 each group). At the end of 25th day, the serum cholesterol, triglyceride, HDL, LDL and VLDL levels, as well as atherogenic indices were determined in rats’ serum. The ethanolic extract of lavender decreased serum cholesterol, triglyceride, LDL and VLDL levels in 100 mg/Kg group (p=0.03, p=0.001, p=0.001, p=0.001, respectively). Serum HDL level increased in 100 mg/Kg/day group (p=0.01). Lavender extract decreased LDL/HDL level at doses of 100 and 200 mg/Kg/day (p=0.001, p=0.001, respectively). The TG/HDL levels decreased in experimental groups with doses of 100 and 200 mg/Kg/day (p=0.001, p=0.001, respectively). Lavandula officinalis extract exerts hypolipidemic effect in rats and might be beneficial in hyperlipidemic patients.

 
Keyword(s): LAVANDULA OFFICINALIS, SERUM LIPIDS, ATHEROGENIC INDEX, CARDIOVASCULAR
 
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