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Paper Information

Journal:   ACTA MEDICA IRANICA   2014 , Volume 52 , Number 9; Page(s) 651 To 655.
 
Paper: 

STEM CELL THERAPY FOR TREATMENT OF EPILEPSY

 
 
Author(s):  GOODARZI PARISA, AGHAYAN HAMID REZA, SOLEIMANI MASOUD, NOROUZI JAVIDAN ABBAS, MOHAMADI JAHANI FERESHTEH, JAHANGIRI SHARAREH, EMAMI RAZAVI SEYED HASAN, LARIJANI BAGHER, ARJMAND BABAK*
 
* ENDOCRINOLOGY AND METABOLISM RESEARCH CENTER, TEHRAN UNIVERSITY OF MEDICAL SCIENCES, TEHRAN, IRAN
 
Abstract: 

Epilepsy as one of the most common neurological disorders affects more than 50 million people worldwide with a higher prevalence rate in low-income countries. Excessive electrical discharges in neurons following neural cell damage or loss cause recurrent seizures. One of the most common and difficult to treat types of epilepsy is temporal lobe epilepsy (TLE) which results from hippocampal sclerosis. Nowadays, similar to other diseases, epilepsy also is a candidate for treatment with different types of stem cells. Various stem cell types were used for treatment of epilepsy in basic and experimental researches. Two major roles of stem cell therapy in epilepsy are prophylaxis against chronic epilepsy and amelioration cognitive function after the occurrence of TLE. Several animal studies have supported the use of these cells for treating drugresistant TLE. Although stem cell therapy seems like a promising approach for treatment of epilepsy in the future however, there are some serious safety and ethical concerns that are needed to be eliminated before clinical application.

 
Keyword(s): CELL THERAPY, EPILEPSY, STEM CELL, TREATMENT
 
References: 
 
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