Click for new scientific resources and news about Corona[COVID-19]

Paper Information

Journal:   IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)   2014 , Volume 13 , Number 4; Page(s) 1313 To 1318.
 
Paper: 

ANTIHYPERGLYCEMIC AND ANTIHYPERLIPIDEMIC EFFECTS OF FRUIT AQUEOUS EXTRACT OF BERBERIS INTEGERRIMA BGE. IN STREPTOZOTOCIN-INDUCED DIABETIC RATS

 
 
Author(s):  ASHRAFI HOSSEIN*, HEIDARI REZA, NEJATI VAHID
 
* DEPARTMENT OF BIOLOGY, FACULTY OF SCIENCE, URMIA UNIVERSITY, URMIA, IRAN
 
Abstract: 

Use of medicinal plants for attenuation of hyperglycemia and restoration of lipids disorder to normal level is clinically very important. The aim of present study was to evaluate the effects of Berberis integerrima Bge. fruit aqueous extract (BIFAE) on blood glucose and lipid profile in streptozotocin (STZ) - induced diabetic rats. The STZ-induced diabetic rats were treated by fruit aqueous extract of Berberis integerrima Bge. at doses (250 and 500 mg/Kg bw) and glibenclamide (0.6 mg/Kg bw) for 42 days by gavage. Blood glucose levels and body weights of rats were measured on weeks 0, 2, 4 and 6. Total lipid levels were determined in normal and STZ-induced diabetic rats after administration of the BIFAE and glibenclamide for 42 days. STZ-induced diabetic rats showed a significant (P<0.001) increases in the levels of blood glucose, triglycerides (TG), total cholesterol (TC), low density lipoprotein LDL-cholesterol (LDL-C) while body weight and high density lipoprotein HDL-cholesterolan (HDL-C) were significantly (P<0.001) decreased compared to normal rats. Daily administration of BIFAE did not possess the hypoglycemic and hypolipidaemic activity in STZ- diabetic rats during 6-week treatment period. Results indicate the usage of BIFAE in traditional medicine for the treatment of diabetes may need more investigation.

 
Keyword(s): BERBERIS INTEGERRIMA, DIABETES MELLITUS, HYPERGLYCEMIA, HYPERLIPIDEMIA, RAT
 
References: 
  • ندارد
 
  pdf-File tarjomyar Yearly Visit 56
 
Latest on Blog
Enter SID Blog