Paper Information

Journal:   IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)   2014 , Volume 13 , Number 4; Page(s) 1425 To 1430.
 
Paper: 

PROCERENONE: A FATTY ACID TRITERPENOID FROM THE FRUIT PERICARP OF OMPHALOCARPUM PROCERUM (SAPOTACEAE)

 
Author(s):  NGAMGWE ROSINE FOTSING, YANKAM RAOUL, CHOUNA JEAN RODOLPHE, LANZ CHRISTIAN, FURRER JULIEN, SCHURCH STEFAN, KAISER MARCEL, LENTA BRUNO NDJAKOU*, NGOUELA SILVERE, TSAMO ETIENNE, BRENNEISEN RUDOLF
 
* DEPARTMENT OF CHEMISTRY, HIGHER TEACHER TRAINING COLLEGE, UNIVERSITY OF YAOUNDE 1, YAOUNDE, CAMEROON
 
Abstract: 

Phytochemical investigation of a dichloromethane-methanol (1: 1) extract of the fruit pericarp of Omphalocarpum procerum which exhibited antiplasmodial activity during preliminary screening led to the isolation of the new fatty ester triterpenoid 3b-hexadecanoyloxy-28- hydroxyolean-12-en-11-one (1), together with five known compounds 2-6. The structure of the new compound as well as those of the known compounds was established by means of spectroscopic methods and by comparison with previously reported data. Compounds 1- 4 were evaluated in-vitro for their cytotoxicity against L6 cell lines and antiprotozoal activities against Plasmodium falciparum, Leishmania donovani, Trypanosoma brucei rhodesiense and Trypanosoma cruzi (species responsible for human malaria, visceral leishmaniasis, African trypanosomiasis and Chagas disease, respectively). The tested compounds showed weak to moderate antiprotozoal activity and, no significant effect was detected regarding their cytotoxic potency.

 
Keyword(s): SAPOTACEAE, OMPHALOCARPUM PROCERUM, TRITERPENOID, PROCERENONE, ANTIPARASITIC ACTIVITY
 
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