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Paper Information

Journal:   IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)   2014 , Volume 13 , Number 4; Page(s) 1369 To 1378.
 
Paper: 

PROTECTIVE EFFECTS OF LINDERA COREANA ON UVB-INDUCED OXIDATIVE STRESS IN HUMAN HACAT KERATINOCYTES

 
 
Author(s):  SONG JIA LE, GAO YANG*
 
* DEPARTMENT OF PHARMACY, NORTHERN JIANGSU PEOPLE’S HOSPITAL AFFILIATED TO YANGZHOU UNIVERSITY (CLINICAL MEDICAL COLLEGE OF YANGZHOU UNIVERSITY), YANGZHOU, JIANGSU 225001,PEOPLES REPUBLIC OF CHINA
 
Abstract: 

The present study was designed to investigate the protective effect of ethanol extracts from Lindera coreana leaves (LCE) on UVB-induced oxidative stress in HaCaT keratinocytes. The HaCaT cells were pretreated with LCE for 24 h and then exposed to UVB (20 mJ/cm2) for 2 h. UVB significantly decreased the cell viability (p<0.05). LCE did not exhibit significantly cytotoxic effects and increased the viability of the HaCaT cells in a concentration-dependent manner. To further investigate the protective effects of LCE on UVB-induced oxidative stress in HaCaT cells, the cellular levels of reactive oxygen species (ROS), lipid peroxidation and endogenous antioxidant enzymes, including catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GSH-px), were analyzed. LCE decreased the intracellular levels of ROS and lipid peroxidation and increased the activity of antioxidant enzymes. These results suggest that LCE exerted cytoprotective activity against UVB-induced oxidative stress in HaCaT cells through the inhibition of lipid peroxidation, reduction of ROS levels and stimulation of antioxidant enzymes activities. In addition, LCE also decreased the TNF-a, IL-1b and IL-6 levels in UVB-irradiated HaCaT cells.

 
Keyword(s): LINDERA COREANA, HACAT KERATINOCYTES, ULTRAVIOLET (UV), REACTIVE OXYGEN SPECIES (ROS), ANTIOXIDANT ENZYMES
 
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