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Paper Information

Journal:   ANESTHESIOLOGY AND PAIN MEDICINE   OCTOBER 2014 , Volume 4 , Number 4; Page(s) 0 To 0.
 
Paper: 

THE EFFECT OF DEFASCICULATING DOSES OF PANCURONIUM AND ATRACURIUM ON SUCCINYLCHOLINE NEUROMUSCULAR BLOCKADE

 
 
Author(s):  MOTAMED CYRUS*, PHILIPPE DUVALDESTIN
 
* DEPARTMENT OF ANESTHESIA, GUSTAVE ROUSSY INSTITUTE, RUE CAMILLE DESMOULINS 94080 VILLEJUIF, FRANCE UNIVERSITY OF PARIS 11, PARIS, FRANCE
 
Abstract: 

Background: A defasciculating dose of non-depolarizing muscle relaxant administered prior succinylcholine decrease its side effects including fasciculations and postoperative myalgias; however it is believed that the dosage of succinylcholine should be increased when such a pre-treatment is used.
Objectives: We hypothesized that a defasciculating dose of pancuronium as a pre-treatment could prolong its duration of effect.
Patients and Methods: Forty patients scheduled for elective orthopaedic surgery were consecutively assigned into 5 groups, a first group without pre-treatment (succinylcholine 1 mg/kg) and 4 subsequent groups of pretreatment with atracurium 0.05 mg/kg+succinylcholine 1 or 1.5 mg/kg and pancuronium 7.5
mg/kg+succinylcholine 1 and 1.5 mg/kg. The muscle relaxant effect of succinylcholine was assessed with a force transducer using train of four stimulations every 12 seconds. Kruskall Wallis Anova test was used to compare results.
Results: The duration of succinylcholine induced paralysis (1 and 1.5 mg/kg) was significantly prolonged with pre-treatment with pancuronium but succinylcholine 1mg/kg did not reached maximum blockade after pre-treatment with atracurium. After pancuronium, full recovery after succinylcholine 1.5 and 1 mg/kg occurred respectively after 18 and 15 minutes. P<0.05 vs.12 minutes for succinylcholine 1mg/kg alone.
Conclusions: This study highlights potentiation effect of a defasciculating dose of pancuronium on succinylcholine paralysis suggesting the lack of justification to increase succinylcholine dosage.

 
Keyword(s): SUCCINYLCHOLINE, ATRACURIUM, PANCURONIUM
 
References: 
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