Serum Inflammatory Markers In The Elderly: Are They Useful In Differentiating Sepsis From Sirs?

TALEBI TAHER MAHSHID; BABAZADEH SHAHIN; BARATI MITRA; LATIFNIA MARYAM

Paper Information


Journal: ACTA MEDICA IRANICA 2014 , Volume 52 , Number 6; Page(s) 438 To 442.

Paper: Serum Inflammatory Markers In The Elderly: Are They Useful In Differentiating Sepsis From Sirs?



Author(s): Talebi Taher Mahshid*, Babazadeh Shahin, Barati Mitra, Latifnia Maryam

* DEPARTMENT OF GERIATRIC MEDICINE, ANTIMICROBIAL-RESISTANT RESEARCH CENTER, TEHRAN UNIVERSITY OF MEDICAL SCIENCES, TEHRAN, IRAN

Abstract: Differentiating sepsis from other noninfectious causes of systemic inflammation is often difficult in the elderly. The aim of this study was to evaluate the ability of C-reactive protein (CRP), Erythrocyte Sedimentation Rate (ESR), procalcitonin (PCT), and Interleukin-6 (IL-6) to identify elderly patients with sepsis. In this single center prospective observational study, we included all consecutive elderly patients admitted with suspected sepsis and systemic inflammatory response syndrome (SIRS) in an emergency department. Blood samples for measuring CRP, PCT, IL-6, ESR and white blood cells (WBC) count were taken at first day of admission. Sensitivity, specificity, positive and negative predictive values were calculated for each inflammatory markers being studied. A total of 150 elderly patients aged 65 and older, 50 with sepsis and 50 with SIRS, and fifty individuals in a normal health status were included. CRP exhibited the greatest sensitivity (98%) and negative predictive value (98.6%) and performed best in differentiating patients with sepsis from those with SIRS. In a receiver operating characteristic curve analysis, IL-6 performed best in distinguishing between SIRS and the control group (AUC 0.75, 95% CI). On the other hand, both CRP and ESR appeared to be a more accurate diagnostic parameter for differentiating sepsis from SIRS among elderly patients.

Keyword(s): SEPSIS, C-REACTIVE PROTEIN, ESR, PCT, IL-6



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+ Click to Cite. APA: Copy TALEBI TAHER, M., & BABAZADEH, S., & BARATI, M., & LATIFNIA, M. (2014). SERUM INFLAMMATORY MARKERS IN THE ELDERLY: ARE THEY USEFUL IN DIFFERENTIATING SEPSIS FROM SIRS?. ACTA MEDICA IRANICA, 52(6), 438-442. https://www.sid.ir/en/journal/ViewPaper.aspx?id=409621 Vancouver: Copy TALEBI TAHER MAHSHID, BABAZADEH SHAHIN, BARATI MITRA, LATIFNIA MARYAM. SERUM INFLAMMATORY MARKERS IN THE ELDERLY: ARE THEY USEFUL IN DIFFERENTIATING SEPSIS FROM SIRS?. ACTA MEDICA IRANICA. 2014 [cited 2022June30];52(6):438-442. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=409621 IEEE: Copy TALEBI TAHER, M., BABAZADEH, S., BARATI, M., LATIFNIA, M., 2014. SERUM INFLAMMATORY MARKERS IN THE ELDERLY: ARE THEY USEFUL IN DIFFERENTIATING SEPSIS FROM SIRS?. ACTA MEDICA IRANICA, [online] 52(6), pp.438-442. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=409621.

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Serum Inflammatory Markers In The Elderly: Are They Useful In Differentiating Sepsis From Sirs?