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Paper Information

Journal:   IRANIAN JOURNAL OF PUBLIC HEALTH   AUGUST 2014 , Volume 43 , Number SUPPLEMENT 2; Page(s) 19 To 19.
 
Paper: 

RISK FACTORS ASSOCIATED WITH COMMUNITY-ACQUIRED TEM PRODUCING KLEBSIELLA PNEUMONIA

 
 
Author(s):  RAMAZANZADEH RASHID*, AHMADIZAD MEHRAN, KESHAVARZI FATEMEH
 
* CELLULAR AND MOLECULAR RESEARCH CENTER AND MICROBIOLOGY DEPARTMENT, FACULTY OF MEDICINE, KURDISTAN UNIVERSITY OF MEDICAL SCIENCES, SANANDAJ, IRAN
 
Abstract: 

Background: Antibiotic resistance is one of the major challenges in bacterial infection control. ESBLs- (Extended spectrum beta lactamases) are the groups of enzymes in which enable the bacteria to become resistant to different types of antibiotics. The aim of this study is to investigate risk factors associated with TEM gene in the Klebsiella pneumoniae isolates which collected from the laboratories of the city.
Methods: The study was a case-control investigation. A case patient was defined as a patient who had one isolate of a TEM gene positive Klebsiella pneumoniae strain. A control patient was defined as a patient who had one isolate of a TEM gene negative Klebsiella pneumoniae strain. TEM gene was determined by using double disk diffusion antibiotic susceptibility technique and PCR Method.
Results: There were a significant correlation between history of antibiotic use over the past 3 month (OR=3.68, 95% CI: 1.21–11.19 P
<0.022), close contact with family working in hospital (OR=7.29, 95% CI: 2.09–25.42 P<0.05) and home distance from hospital under 2 km (OR=3.08, 95% CI: 1.10–8.58 P<0.032) with the presence of TEM Genes.
Conclusion: The main risk factors associated with community- acquired TEM producing Klebsiella pneumonia strains were history of antibiotic use over the past 3 month, close contact with family working in hospital and home distance from hospital under 2 km. More studies are needed to evaluate the role of these factors in order to control the spread of drug resistance.

 
Keyword(s): KLEBSIELLA PNEUMONIA, RISK FACTOR, TEM, EXTENDED- SPECTRUM ?- LACTAMASES
 
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