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Journal:   ACTA MEDICA IRANICA   2014 , Volume 52 , Number 6; Page(s) 418 To 423.
 
Paper: 

The Influence Of Combined Genotypes Of The Hladrb1*1501 And Cd24 Single Nucleotide Polymorphism On Disease Severity Of Iranian Multiple Sclerosis Patients

 
 
Author(s):  Ghlichnia Hossein Ali, Kollaee Abolghasem, Gaffarpoor Majid, Movafagh Abolfazl, Ghlichnia Babak, Zamani Mahdi*
 
* DEPARTMENT OF NEUROGENETICS, IRANIAN CENTER OF NEUROLOGICAL RESEARCH, TEHRAN, IRAN
 
Abstract: 
Multiple Sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system.It is a clinically heterogeneous disorder especially in terms of disease severity. Current investigations suggest that genes and gene-gene interactions not only influence on susceptibility to MS but also affect the disease severity. In this study, we investigated the contribution of the HLADRB1*1501 allele and single nucleotide polymorphism (SNP) in CD24 gene and also combined genotypes of the HLADRB1*1501 and CD24 SNP to disease severity in Iranian MS patients. We have reported previously that the HLA- DRB1*1501 allele and the CD24v/v genotype associated with disease susceptibility and some other studies proposed that HLADRB1* 1501 allele be associated with MS severity. In this study, the results showed a significant difference in the Multiple Sclerosis Severity Score (MSSS) of the nine different genotypes (F=2.838, P=0.007).Subsequent analysis revealed a statistically significant difference in the MSSS between the MS patients who were carriers of HLA-DRB1*1501/1501 and those who were not carriers of HLA-DRB1*1501/1501 genotypes (P=0.04). Moreover, the MS patients carrying combined genotypes of the HLA- DRB1*1501/x- CD24 v/v had statistically severe disease than the patients who did not carry the HLA- DRB1*1501- CD24 v/v (P=0.047). In conclusion, our findings suggest that, HLA-DRB1*1501/1501 and bigenic genotypes of the HLA- DRB1*1501/x- CD24 v/v may influence on disease severity in Iranian MS patients.
 
Keyword(s): MULTIPLE SCLEROSIS, HLA-DRB1*1501, CD24, MSSS
 
 
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APA: Copy

GHLICHNIA, H., & KOLLAEE, A., & GAFFARPOOR, M., & MOVAFAGH, A., & GHLICHNIA, B., & ZAMANI, M. (2014). THE INFLUENCE OF COMBINED GENOTYPES OF THE HLADRB1*1501 AND CD24 SINGLE NUCLEOTIDE POLYMORPHISM ON DISEASE SEVERITY OF IRANIAN MULTIPLE SCLEROSIS PATIENTS. ACTA MEDICA IRANICA, 52(6), 418-423. https://www.sid.ir/en/journal/ViewPaper.aspx?id=409616



Vancouver: Copy

GHLICHNIA HOSSEIN ALI, KOLLAEE ABOLGHASEM, GAFFARPOOR MAJID, MOVAFAGH ABOLFAZL, GHLICHNIA BABAK, ZAMANI MAHDI. THE INFLUENCE OF COMBINED GENOTYPES OF THE HLADRB1*1501 AND CD24 SINGLE NUCLEOTIDE POLYMORPHISM ON DISEASE SEVERITY OF IRANIAN MULTIPLE SCLEROSIS PATIENTS. ACTA MEDICA IRANICA. 2014 [cited 2022July01];52(6):418-423. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=409616



IEEE: Copy

GHLICHNIA, H., KOLLAEE, A., GAFFARPOOR, M., MOVAFAGH, A., GHLICHNIA, B., ZAMANI, M., 2014. THE INFLUENCE OF COMBINED GENOTYPES OF THE HLADRB1*1501 AND CD24 SINGLE NUCLEOTIDE POLYMORPHISM ON DISEASE SEVERITY OF IRANIAN MULTIPLE SCLEROSIS PATIENTS. ACTA MEDICA IRANICA, [online] 52(6), pp.418-423. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=409616.



 
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