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Paper Information

Journal:   ANESTHESIOLOGY AND PAIN MEDICINE   OCTOBER 2014 , Volume 4 , Number 4; Page(s) 0 To 0.
 
Paper: 

ATTENUATION OF CISPLATHIN-INDUCED TOXIC OXIDATIVE STRESS BY PROPOFOL

 
 
Author(s):  TAHERI MOGHADAM GHAZALEH, HOSSEINI ZIJOUD SEYED MOSTAFA, HEIDARY SHAYESTEH TAVAKOL, GHASEMI HASAN, RANJBAR AKRAM*
 
* DEPARTMENT OF TOXICOLOGY AND PHARMACOLOGY, SCHOOL OF PHARMACY, HAMADAN UNIVERSITY OF MEDICAL SCIENCES, HAMADAN, IRAN
 
Abstract: 

Background: Antioxidant effects of propofol (2, 6-diisopropylphenol) were evaluated against cisplatin-induced oxidative stress in rat.
Objectives: In this experimental study, 20 male rats were equally divided into 4 groups (5 rats each), and were treated by propofol (10 mg/kg/day, IP), or cisplatin (7 mg /kg/day, IP), or both.
Materials and Methods: Group one was control, while group 2 was given cisplatin (7 mg /kg/day, IP). Animals of the third group received only propofol (10 mg/kg/day, IP). Group 4 was given propofol with cisplatin once per day for 7 days. After treatment, blood urea nitrogen, creatinine levels, and oxidative stress m arkers such as total thiol groups (TTG), lipid peroxidation (LPO), and total antioxidant capacity (TAC) were measured.
Results: Oxidative stress induced by cisplatin, was evident by a significant increase in LPO and decrease in TTG and TAC. Propofol recovered cisplatin-induced changes in TAC, TTG and LPO in blood.
Conclusions: It is concluded that oxidative damage is the mechanism of cisplatin toxicity, which can be recovered by propofol.

 
Keyword(s): PROPOFOL, CISPLATIN, OXIBDATIVE STRESS, RAT
 
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