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Paper Information

Journal:   IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)   2014 , Volume 13 , Number 4; Page(s) 1319 To 1325.
 
Paper: 

ANETHOLE, A MEDICINAL PLANT COMPOUND, DECREASES THE PRODUCTION OF PRO-INFLAMMATORY TNF-α AND IL-1β IN A RAT MODEL OF LPS-INDUCED PERIODONTITIS

 
 
Author(s):  MORADI JANET, ABBASIPOUR FATEMEH*, ZARINGHALAM JALAL, MALEKI BITA, ZIAEE NARGES, KHODADOUSTAN AMIN, JANAHMADI MAHYAR*
 
* NEUROPHYSIOLOGY RESEARCH CENTRE (NPRC) AND DEPARTMENT OF PHYSIOLOGY, MEDICAL SCHOOL, SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES, EVIN, TEHRAN, IRAN
 
Abstract: 

Periodontitis (PD) is known to be one of most prevalent worldwide chronic inflammatory diseases. There are several treatments including antibiotics for PD; however, since drug resistance is an increasing problem, new drugs particularly derived from plants with fewer side effects are required. The effects of trans-anethole on IL-1 b and TNF-a level in a rat model of PD were investigated and compared to ketoprofen.
Eschericia coli lipopolysaccharide (LPS, 30
mg) was injected bilaterally into the palatalgingiva (3 mL/site) between the upper first and second molars every two days for 10 days in anesthetized rats. Administration of either trans-anethole (10 or 50 mg/Kg, i.p.) or ketoprofen (10 mg/Kg, i.p.) was started 20 minute before LPS injection and continued for 10 days. Then, IL-1b and TNF-a levels were measured in blood samples by ELISA at day 0 (control) and at day 10.
Anethole at both concentrations significantly suppressed IL-1
b and TNF-a productionwhen compared to LPS-treated rats. The suppressive effects of anethole on LPS-induced pro-inflammatory cytokines were almost similar as seen with ketoprofen.
In conclusion, the present results suggest that anethole may have a potent inhibitory effecton PD through suppression of pro-inflammatory molecules; therefore it could be a novel therapeutic strategy for PD.

 
Keyword(s): TRANS-ANETHOLE, LPS-INDUCED PERIODONTITIS, KETOPROFEN, ANTI-INFLAMMATORY, IL-1β, TNF-α
 
 
References: 
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Citations: 
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APA: Copy

MORADI, J., & ABBASIPOUR, F., & ZARINGHALAM, J., & MALEKI, B., & ZIAEE, N., & KHODADOUSTAN, A., & JANAHMADI, M. (2014). ANETHOLE, A MEDICINAL PLANT COMPOUND, DECREASES THE PRODUCTION OF PRO-INFLAMMATORY TNF-α AND IL-1β IN A RAT MODEL OF LPS-INDUCED PERIODONTITIS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 13(4), 1319-1325. https://www.sid.ir/en/journal/ViewPaper.aspx?id=409603



Vancouver: Copy

MORADI JANET, ABBASIPOUR FATEMEH, ZARINGHALAM JALAL, MALEKI BITA, ZIAEE NARGES, KHODADOUSTAN AMIN, JANAHMADI MAHYAR. ANETHOLE, A MEDICINAL PLANT COMPOUND, DECREASES THE PRODUCTION OF PRO-INFLAMMATORY TNF-α AND IL-1β IN A RAT MODEL OF LPS-INDUCED PERIODONTITIS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR). 2014 [cited 2021November27];13(4):1319-1325. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=409603



IEEE: Copy

MORADI, J., ABBASIPOUR, F., ZARINGHALAM, J., MALEKI, B., ZIAEE, N., KHODADOUSTAN, A., JANAHMADI, M., 2014. ANETHOLE, A MEDICINAL PLANT COMPOUND, DECREASES THE PRODUCTION OF PRO-INFLAMMATORY TNF-α AND IL-1β IN A RAT MODEL OF LPS-INDUCED PERIODONTITIS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), [online] 13(4), pp.1319-1325. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=409603.



 
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