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Paper Information

Journal:   IRANIAN JOURNAL OF PUBLIC HEALTH   AUGUST 2014 , Volume 43 , Number 8; Page(s) 1060 To 1069.
 
Paper: 

RELATIONSHIP BETWEEN CATSPERB, NR5A2 GENE POLYMORPHISMS AND PEAK BONE MINERAL DENSITY IN COLLEGE STUDENTS IN CHINA

 
 
Author(s):  ZHAO YUAN, LIU WENYA*, HUA MA, SHI RAONI, WANG HAITAO, YANG WEN
 
* IMAGING CENTER, FIRST AFFILIATED HOSPITAL, XINJIANG MEDICAL UNIVERSITY, URUMQI 830054, XINJIANG, CHINA
 
Abstract: 

Background: Peak bone mineral density (PBMD) is influenced by both genetic and environmental factors, genes explains most of variation. As the novel candidate genes CATSPERB and NR5A2 may have been associated with spinal PBMD in adult. This study was to investigate the relationship among these two genes PBMD and the life style factors in young female.
Methods: The rs1298989 single nucleotide polymorphism (SNP) of the CATSPERB gene and the rs3762397 SNP of the NR5A2 gene were genotyped using SNaPshot® in 359 students from Xinjiang. The prospective study included 203 Han and 156 Uyghur subjects. PBMD was measured using quantitative computed tomography (QCT). Calcium, phosphate and alkaline phosphatase were measured by ELISA method. Physical activity, dietary calcium and life styles were assessed by questionnaire.
Results: Both SNPs showed differences in genotype and allele frequencies (P<0.05) between the Han and Uyghur subjects. Total calcium intake, energy intake, tea and milk intake were also significantly different between two groups (P<0.05). Multiple regression analysis showed an association between PBMD and vitamin D intake (P= 0.000), milk (P=0.000), exercise (P=0.029), rs1298989 (P=0.028), energy intake (P=0.043).
Conclusion: This study demonstrated the polymorphisms of the rs1298989 and rs3762397 are associated with PBMD both in Han and Uyghur subjects. PBMD, in Xinjiang, appears to be associated with several known factors that are well described in the literature. While the genotypes of rs1298989 and rs3762397 do not appear have a strong effect on the PBMD.

 
Keyword(s): PEAK BONE MINERAL DENSITY (PBMD), LIFE STYLES, CATSPERB, RS1298989 NR5A2, RS3762397
 
 
References: 
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Citations: 
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APA: Copy

ZHAO, Y., & LIU, W., & HUA, M., & SHI, R., & WANG, H., & YANG, W. (2014). RELATIONSHIP BETWEEN CATSPERB, NR5A2 GENE POLYMORPHISMS AND PEAK BONE MINERAL DENSITY IN COLLEGE STUDENTS IN CHINA. IRANIAN JOURNAL OF PUBLIC HEALTH, 43(8), 1060-1069. https://www.sid.ir/en/journal/ViewPaper.aspx?id=409596



Vancouver: Copy

ZHAO YUAN, LIU WENYA, HUA MA, SHI RAONI, WANG HAITAO, YANG WEN. RELATIONSHIP BETWEEN CATSPERB, NR5A2 GENE POLYMORPHISMS AND PEAK BONE MINERAL DENSITY IN COLLEGE STUDENTS IN CHINA. IRANIAN JOURNAL OF PUBLIC HEALTH. 2014 [cited 2021October16];43(8):1060-1069. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=409596



IEEE: Copy

ZHAO, Y., LIU, W., HUA, M., SHI, R., WANG, H., YANG, W., 2014. RELATIONSHIP BETWEEN CATSPERB, NR5A2 GENE POLYMORPHISMS AND PEAK BONE MINERAL DENSITY IN COLLEGE STUDENTS IN CHINA. IRANIAN JOURNAL OF PUBLIC HEALTH, [online] 43(8), pp.1060-1069. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=409596.



 
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