|
Journal:
IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)
2014
, Volume 13
, Number 4; Page(s)
1213
To
1219. |
|
Paper:
Meta-Analysis Of Selective Serotonin Reuptake Inhibitors (Ssris) Compared To Tricyclic Antidepressants (Tcas) In The Efficacy And Safety Of Anti-Depression Therapy In Parkinson’S Disease(Pd) Patients
|
|
|
|
Author(s):
Qiu Bao Yue, Qiao Jun Xiao, Yong Jiang*
|
|
* DEPARTMENT OF MEDICAL ENGINEERING, GENERAL HOSPITAL OF THE SECOND ARTILLERY, BEIJING 100088, CHINA |
|
Abstract:
To assess the efficacy and safety of selective serotonin reuptake inhibitors (SSRIs) and tricyclic antidepressants (TCAs) in treatment of Parkinsonian depression.A computer-based search was conducted in the databases of PUBMED, MEDLINE, EMBASE and CochraneControlled Trails Register up to December 2011. The random controlled clinic trials about SSRIs and TCAs in treatment of Parkinsonian depression were collected. Statistical analysis was completed using Review Manager, version 5.0.Five clinic controlled trials were identified for this meta-analysis. There was no significant statistical difference in the response rate of treatment [RR 0.95, 95%CI (0.78, 1.16)] andHamilton depression score [RR -2.54, 95%CI (-5.35, 0.26)] between two groups. In term of complications, no statistical difference was observed in the insomnia rate between two groups [RR 0.82, 95%CI (0.24, 2.84)]. Moreover, the incidence rate of xerostomia [RR 0.21, 95%CI (0.07, 0.65)] and constipation [RR 0.12, 95%CI (0.02, 0.63)] was lower in SSRIs group rather than those in TCAs group.In general, SSRIs and TCAs have comparable efficacy and equal acceptability in treatment of Parkinson’s disease-induced depression. However, SSRIs are superior to TCAs in the terms of xerostomia and constipation.
|
|
Keyword(s): META-ANALYSIS, SELECTIVE SEROTONIN REUPTAKE INHIBITORS (SSRIS), TRICYCLIC ANTI-DEPRESSANTS (TCAS), EFFICACY, COMPLICATION |
|
|
|
International related papers:
|
|
Most related
Highly related
Moderately related
Least related |
|
References:
|
|
Citations:
|
|
+ Click to Cite.
APA: CopyQIU, B., & QIAO, J., & YONG, J. (2014). META-ANALYSIS OF SELECTIVE SEROTONIN REUPTAKE INHIBITORS (SSRIS) COMPARED TO TRICYCLIC ANTIDEPRESSANTS (TCAS) IN THE EFFICACY AND SAFETY OF ANTI-DEPRESSION THERAPY IN PARKINSON’S DISEASE(PD) PATIENTS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 13(4), 1213-1219. https://www.sid.ir/en/journal/ViewPaper.aspx?id=409595 Vancouver: CopyQIU BAO YUE, QIAO JUN XIAO, YONG JIANG. META-ANALYSIS OF SELECTIVE SEROTONIN REUPTAKE INHIBITORS (SSRIS) COMPARED TO TRICYCLIC ANTIDEPRESSANTS (TCAS) IN THE EFFICACY AND SAFETY OF ANTI-DEPRESSION THERAPY IN PARKINSON’S DISEASE(PD) PATIENTS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR). 2014 [cited 2022June30];13(4):1213-1219. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=409595 IEEE: CopyQIU, B., QIAO, J., YONG, J., 2014. META-ANALYSIS OF SELECTIVE SEROTONIN REUPTAKE INHIBITORS (SSRIS) COMPARED TO TRICYCLIC ANTIDEPRESSANTS (TCAS) IN THE EFFICACY AND SAFETY OF ANTI-DEPRESSION THERAPY IN PARKINSON’S DISEASE(PD) PATIENTS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), [online] 13(4), pp.1213-1219. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=409595.
|
|
Yearly Visit 39
|
|
|
|
|
|