Paper Information

Journal:   IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)   2014 , Volume 13 , Number 4; Page(s) 1191 To 1201.
 
Paper: 

STUDY ON THE MULTI-MARKER COMPONENTS QUANTITATIVE HPLC FINGERPRINT OF THE COMPOUND CHINESE MEDICINE WUWEI CHANGYANNING GRANULE

 
 
Author(s):  YANG XIAN, YANGA SHUI PING, ZHANG XUE*, YU XIAO DONG, HE QI YI, WANG BO CHU
 
* CHONGQING ACADEMY OF CHINESE MATERIA MEDICA, CHONGQING 400065, P.R.CHINA
 
Abstract: 

The aim of this paper is to develop a rapid and highly sensitive quantitative HPLC fingerprint method with multiple indicators by using the Compound Chinese Medicine Wuwei Changyanning granule and 5 herbs in the prescription. The quantitative fingerprint chromatogram with multiple indicators was investigated. i) 6 compositions included rutin, gallic acid, chlorogenic acid, atractylenolide i, pachymic acid and apigenin, which originated from 5 herbs respectively, were selected as quantitative compositions, and their contents were determined using HPLC from 11 batches granules and the corresponding 5 medicinal materials. ii) The precision, stability and repeatability of fingerprinting were investigated. In addition, common peaks number, the percentage of non-common peaks and similarity were also studied. Among them, 21 common peaks in the granule could find the source of peaks from the 5 herbs, among of 10 peaks from Niuerfeng, 9 peaks from Laliao, 3 peaks from Baishu, 3 peaks from Fuling and 5 peaks from Guanghuoxiang. The results showed that the identification method of fingerprinting was reliable.

 
Keyword(s): THE MULTIPLE INDICATOR, HPLC FINGERPRINT, WUWEI CHANGYANNING GRANULE, COMMON PEAKS NUMBER, THE PERCENTAGE OF NON-COMMON PEAKS AND SIMILARITY
 
References: 
  • ندارد
 
  pdf-File tarjomyar Yearly Visit 52
 
Latest on Blog
Enter SID Blog