Paper Information

Journal:   IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI)   DECEMBER 2014 , Volume 13 , Number 6; Page(s) 412 To 419.
 
Paper: 

INTERLEUKIN-25 ENHANCES ALLERGIC INFLAMMATION THROUGH P38MAPK AND NF-KB PATHWAYS IN MOUSE MODELS OF ALLERGIC RHINITIS

 
 
Author(s):  LI ZHIPENG, WANG HUI, LIU LISI*
 
* DEPARTMENT OF OTORHINOLARYNGOLOGY HEAD AND NECK SURGERY, TONGJI HOSPITAL, TONGJI MEDICAL COLLEGE, HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY, WUHAN430030, P.R. CHINA
 
Abstract: 

Interleukin (IL) -25, a cytokine of IL-17 family, can activate p38 Mitogen-Activated Protein kinases (MAPK) and Nuclear Factor (NF) -c B pathways to propagate Th2 responses.
The allergic rhinitis mouse model was established by stimulating BALB/c mouse with ovalbumin (OVA). Then we detected expression of IL-25 and downstream p38MAPK and NF-
cB.
The expression of IL-25, p38MAPK and NF-
cB were detected in the OVA-induced allergic rhinitis mouse model. The allergic parameters, such as allergic symptoms, serum OVA-specific immunoglobulin E (IgE) levels and eosinophil infiltration in the nasal mucosa were compared between OVA group and control group.
OVA-induced mice displayed significantly higher allergic responses compared with the saline control group. OVA induced mice demonstrated more allergic symptoms, higher serum OVA-specific IgE levels and eosinophil infiltrations. The increased expression of IL-25, p38MAPK and NF-
cB immunoreactivity were detected in epidermal cells in the OVA group. The mRNA measurement of IL-25, p38MAPK and NF-cB showed the same result.
IL-25 enhances the OVA-induced allergic rhinitis by activating p38MAPK and NF-
cB pathways.

 
Keyword(s): ALLERGIC RHINITIS, INTERLEUKIN-25, MICE, NF-KAPPA B, P38 MITOGEN-ACTIVATED PROTEIN KINASES
 
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