Paper Information

Journal:   JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS)   MARCH 2014 , Volume 19 , Number SUPPLEMENT 1; Page(s) 1 To 4.
 
Paper: 

STATIN EFFICACY IN THE TREATMENT OF HEPATITIS C GENOTYPE I

 
Author(s):  SHAVAKHI AHMAD, MINAKARI MOHAMAD*, BIGHAMIAN AFSHIN, SADEGHIAN SINA, SHAVAKHI SARA, KHAMISI NASER, KHODADUSTAN MAHSA, TALEBI MAJID, ATAEI BEHROOZ
 
* DEPARTMENT OF GASTROENTEROLOGY AND HEPATOLOGY, ISFAHAN UNIVERSITY OF MEDICAL SCIENCES, ISFAHAN, IRAN
 
Abstract: 

Background: Lipid metabolism is one of the hepatitis C virus (HCV) life cycle steps. Statins can reduce cholesterol level and finally can decrease HCV replication. Thus, we assessed the effect of Statins in combination with standard antiviral treatment on hyperlipidemic genotype I HCV infected patients.
Materials and Methods: This study was a prospective clinical trial. 40 patients were selected from those referred to educational and Therapeutic Centers of Isfahan University of Medical Sciences from 2009 to 2010 with confirmed HCV viremia. All patients received Peg-interferon-a2a and ribavirin. 20 hyperlipidemic Patients received 20 mg atorvastatin nightly for 3 months and placebo was prescribed for 20 normolipidemic HCV infected patients as a control group. Liver enzymes and complete blood count were checked monthly and thyroid stimulating hormone was checked every 3 months. We also performed quantitative HCV-ribonucleic acid (RNA) test in 12th week of therapy, at the end of treatment and 6 months after therapy for all samples.
Results: We didn’t find any significant differences in the mean of HCV-RNA numbers between statin and placebo groups in 12th week of treatment, in the end of treatment and 6 months after treatment (P>0.05).
Conclusion: Atorvastatin has no effect on the mean of HCV viral load when we added it to standard treatment for hepatitis C infection. Further studies are necessary to examine the possible antiviral properties of statins and their potential role as adjuncts to standard HCV therapy.

 
Keyword(s): HEPATITIS C, HYPERLIPIDEMIA, STATINS
 
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