Paper Information

Journal:   IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI)   DECEMBER 2014 , Volume 13 , Number 6; Page(s) 404 To 411.
 
Paper: 

DUSTY AIR POLLUTION IS ASSOCIATED WITH AN INCREASED RISK OF ALLERGIC DISEASES IN SOUTHWESTERN PART OF IRAN

 
 
Author(s):  GHEYBI MOHAMMAD KAZZEM, MOVAHED ALI, DEHDARI REYHANEH, AMIRI SHAHRAM, KHAZAEI HOSSEIN ALI, GOOYA MOSTAFA, DEHBASHI FERESHTEH, FATEMI ATENA, SOVID NEDA, HAJIANI GHOLAMREZA, TAHMASEBI RAHIM, DOBARADARAN SINA, FARROKHI SHOKROLLAH*
 
* DEPARTMENT OF IMMUNOLOGY, ASTHMA AND ALLERGY, THE PERSIAN GULF TROPICAL MEDICINE RESEARCH CENTER, BUSHEHR UNIVERSITY OF MEDICAL SCIENCES, SANGI ST, BUSHEHR, IRAN
 
Abstract: 

Concerns have been raised about the adverse impact of dusty air pollution (DAP) on human health. The aim of this study was to find the association between dusty air pollution based on air quality index (AQI) and the risk of allergic diseases in southwestern provinces of Iran, with assessing cytokine profiles and lymphocyte immunophenotypes.
In this case control study 148 individuals participated. The sampling was done in hazardous condition (AQI>300) as the case and clean air (AQI<50) as the control. We measured cytokine production by using ELISA method and phenotypes of T-lymphocytes (CD4+and CD8+), CD19+B-lymphocytes, CD25+, CD4+CD25+cells by FACSort flow cytometer.
The mean serum level of IL-4 (33.4±2.9vs 0.85±0.65 pg/dl) and IL-13 (15.1±4.4 vs. 0.12±0.7 pg/dl) in the subjects exposed to ambient DAP was increased significantly compared to the individuals in the clean air condition. Also, CD19+B-lymphocytes (12.6±4.9 vs 8.9±3.2%) and CD4+CD25+cell count (13.6±4.6 vs 7.7±3.8%) in peripheral blood were increased significantly in subjects exposed to ambient DAP compared with the controls.
The result of our study suggested that ambient DAP affected immune system in a way that might lead to allergic diseases in the population.

 
Keyword(s): ALLERGY, DUSTY AIR POLLUTION, IMMUNE SYSTEM
 
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