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Paper Information

Journal:   INTERNATIONAL JOURNAL OF HEMATOLOGY-ONCOLOGY AND STEM CELL RESEARCH (IJHOSCR)   OCTOBER 2014 , Volume 8 , Number 4; Page(s) 30 To 38.
 
Paper: 

OUTCOME OF ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION IN PATIENTS WITH HEMATOLOGICAL MALIGNANCIES

 
 
Author(s):  ZAHID MOHAMMAD FAIZAN, ALI NATASHA*, SHAIKH MOHAMMAD USMAN
 
* DEPARTMENTS OF PATHOLOGY & MICROBIOLOGY AND ONCOLOGY, THE AGA KHAN UNIVERSITY HOSPITAL, KARACHI, PAKISTAN
 
Abstract: 

Introduction: Allogeneic hematopoietic stem cell transplantation is a potentially curative treatment modality for hematological malignancies. We evaluated the outcome of patients suffering from hematological malignancies, including acute leukemias, chronic myeloid leukemia and myelodysplastic syndrome after allogeneic transplantation.
Methods: All patients having hematological malignancies with HLA identical sibling donors who underwent allogeneic transplantation were included. Pre-transplant workup consisted of complete blood counts, evaluation of liver, kidneys, lungs, infectious profile, chest x-ray, paranasal sinus roentgenograms and dental review. Donors were given G-CSF at a dose of 5-10
mg/kg/twice daily for five days prior to harvest. The conditioning regimens included cyclophosphamide, busulfan and total body irradiation.
Results: A total of 41 allogeneic transplants were performed for hematological malignancies from April 2004 to December 2012. There were 31 males and 10 females. Median age
±SD was 28±11.7 years (range 8 – 54 years). A mean of 7.7x108±1.5 mononuclear cells/kg were infused (range: 6.2-9.2´108/kg). The median time to white cell recovery was 19±4 days (range: 15-23 days). Transplant related mortality was 19.5%. The median overall survival was 53.6 months. Overall survival at a median follow up of 37 months was 67%.
Conclusion: Allogeneic stem cell transplantation is an effective treatment option in patients with hematological malignancies. Our outcomes are comparable with results from neighboring countries as well as the western world.

 
Keyword(s): ALLOGENEIC TRANSPLANTATION, HEMATOPOIETIC STEM CELL TRANSPLANTATION, HEMATOLOGICAL MALIGNANCIES, TREATMENT OUTCOME
 
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