Paper Information

Journal:   IRANIAN JOURNAL OF VETERINARY MEDICINE (INTERNATIONAL JOURNAL OF VETERINARY RESEARCH)   2014 , Volume 8 , Number 2; Page(s) 91 To 99.
 
Paper:  BETAINE AS A METHYL DONOR AND AN ANTIOXIDANT AGENT IN LEVODOPA-INDUCED HYPERHOMOCYSTEINEMIA AND OXIDATIVE STRESS IN RAT'S KIDNEY
 
Author(s):  ALIREZAEI M.*
 
* DIVISION OF BIOCHEMISTRY, SCHOOL OF VETERINARY MEDICINE, LORESTAN UNIVERSITY, KHORRAM ABAD, IRAN
 
Abstract: 

BACKGROUND: Betaine has been shown to be antioxidant and methyl donor effects in our recent studies.
OBJECTIVES: In the present study, the antioxidant and methyl donor properties of betaine in levodopa/benserazide-mediated hyperhomocysteinemia and levodopa-induced oxidative stress in rat's kidney were examined.
METHODS: Sprague-Dawley male rats were divided into levodopa (LD), Betaine (Bet.), levodopa plus betaine (LD/Bet.), levodopa plus benserazide (LD/Ben.), levodopa plus betaine-benserazide (LD/Bet.-Ben.), and control groups. The experimental groups received LD (3×100 mg/kg), Bet. (1.5% w/w of the total diet), Ben. (3×25 mg/kg), and distilled water was given to controls for 10 consecutive days, orally by gavage.
RESULTS: Plasma total homocysteine (tHcy) concentration decreased significantly in Bet.-, LD/Bet.-, and LD/Bet.-Ben.-treated rats compared to LD/Ben. group. Thiobarbituric acid reactive substances concentration (as a lipid peroxidation marker) in renal tissue reduced statistically in betaine group in comparison with LD and LD/Ben. groups. Renal catalase activity increased significantly in LD-treated rats when compared to controls. Renal superoxide dismutase activity significantly decreased in LD-treated group when compared to LD/Ben. group. However, there was not any significant difference in renal glutathione peroxidase (GPx) activity among the groups.
CONCLUSIONS: These findings indicate that LD and LD/Ben. have side effects in kidney due to induction of hyperhomocysteinemia and oxidative stress. In contrast, betaine acts as a promising antioxidant and methyl donor agent versus LD-induced complications.

 
Keyword(s): BENSERAZIDE, BETAINE, HOMOCYSTEINE, KIDNEY, LEVODOPA
 
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