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Paper Information

Journal:   INTERNATIONAL JOURNAL OF HEMATOLOGY-ONCOLOGY AND STEM CELL RESEARCH (IJHOSCR)   OCTOBER 2014 , Volume 8 , Number 4; Page(s) 39 To 44.
 
Paper: 

EVALUATION OF RS3102735 AND RS2073617 OSTEOPROTEGERIN GENE POLYMORPHISMS AND THE RISK OF CHILDHOOD ACUTE LYMPHOBLASTIC LEUKEMIA IN ZAHEDAN SOUTHEAST IRAN

 
 
Author(s):  HASHEMI MOHAMMAD*, EBRAHIMI MAHBOUBEH, AMININIA SHADI, NADERI MAJID, ESKANDARI NASAB EBRAHIM, TAHERI MOHSEN
 
* CLINICAL BIOCHEMISTRY, DEPT. OF CLINICAL BIOCHEMISTRY, SCHOOL OF MEDICINE, ZAHEDAN UNIVERSITY OF MEDICAL SCIENCES, ZAHEDAN, IRAN
 
Abstract: 

Introduction: Osteoprotegerin (OPG), a soluble decoy receptor secreted by osteoblasts, binds RANK-L, preventing stimulation of osteoclastogenesis. In the present study we aimed to investigate the impact of OPG variants and susceptibility to childhood acute lymphocytic leukemia (ALL) in a sample of Iranian population.
Methods: This case-control study was done on 98 ALL and 124 healthy children. We genotyped the polymorphisms using tetra-primer ARMS-PCR (T-ARMS-PCR).
Results: Our findings showed that neither rs3102735 nor rs2073617 variants were associated with ALL in a sample of Iranian population. Concerning rs3102735 polymorphism, the age of ALL predispositions was significantly higher in TC+CC genotype than TT genotype (P=0.032). Furthermore, the CSF involvement was significantly higher in ALL subjects carrying TC+CC genotype (p=0.044).
Conclusion: We found no association between OPG (rs3102735, rs2073617) gene polymorphisms and risk of childhood ALL. Further studies with larger sample sizes and various ethnicities are necessary to verify our findings.

 
Keyword(s): ACUTE LYMPHOCYTIC LEUKEMIA, OSTEOPROTEGERIN, OPG, POLYMORPHISM
 
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