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Paper Information

Journal:   IRANIAN JOURNAL OF PUBLIC HEALTH   JULY 2014 , Volume 43 , Number 7; Page(s) 936 To 946.
 
Paper: 

CHANGES IN PHYSIOLOGICAL PARAMETERS AFTER COMBINED EXERCISE ACCORDING TO THE I/D POLYMORPHISM OF HUCP2 GENE IN MIDDLE-AGED OBESE FEMALES

 
 
Author(s):  DUK OH SANG*
 
* DEPT. OF PHYSICAL EDUCATION, HANYANG UNIVERSITY, SEOUL 133-791, KOREA
 
Abstract: 

Background: The purpose of this study was to determine whether a 45 bp insertion/deletion (I/D) polymorphism in human uncoupling protein 2 (hUCP2) gene was associated with changes in several cardiovascular risk and physical fitness factors in response to combined exercise during 12 weeks in Korean middle-aged women. The changes in physiological parameters after combined exercise during 12 weeks were compared between each genotype subgroups of hUCP2 gene to clarify the inter-individual differences in exercised-induced changes according to genetic predisposition.
Methods: A total of 185 women aged over 40 years living in Seoul, Korea were participated in this study, and analyzed before and after 12 weeks on combined exercise including aerobic exercise and strength training for body composition, hemodynamic parameters, physical fitness and metabolic variables. A 45 bp I/D polymorphism in hUCP2 gene was genotyped by polymerase chain reaction (PCR) amplification and agarose gel electrophoresis method.
Results: Combined exercise program during 12 weeks indicated the significant health-promoting effects for our participants on multiple body composition, hemodynamic parameters, physical fitness factors and metabolic parameters, respectively. With respect to a 45 bp I/D polymorphism in hUCP2 gene, this polymorphism was significantly associated with baseline %body fat of our participants (P<.05). Moreover, this polymorphism was significantly associated with the changes in %body fat and serum triglyceride (TG) level after combined exercise program during 12 weeks (P<.05).
Conclusion: Our data suggest that a 45 bp I/D polymorphism in hUCP2 gene may at least in part contribute to the inter-individual differences on the changes in some clinical and metabolic parameters following combined exercise in middle-aged women.

 
Keyword(s): CARDIOVASCULAR RISK FACTORS, COMBINED EXERCISE, KOREA, HUCP2 AND POLYMORPHISM
 
References: 
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