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Paper Information

Journal:   IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)   2014 , Volume 13 , Number 3; Page(s) 873 To 879.
 
Paper: 

SYNTHESIS OF SOME NOVEL CHROMENOPYRIMIDINE DERIVATIVES AND EVALUATION OF THEIR BIOLOGICAL ACTIVITIES

 
 
Author(s):  MOBINIKHALEDI AKBAR*, FOROUGHIFAR NASER, MOSLEH TAHERE, HAMTA AHMAD
 
* DEPARTMENT OF CHEMISTRY, FACULTY OF SCIENCE, ARAK UNIVERSITY, ARAK 38156-8-8349, IRAN
 
Abstract: 

Pyrimidine nucleosides are constituents of fundamental structure of the cells. There has been considerable attentions in the chemistry of pyrimidine derivatives due to having a wide range of biological activities such as antiviral, anti-malarial agents, cytostatic, antithelemintic, antibacterial, adenosine receptor ligands, anti-cancer agents, compounds targeting delayed-type hypersensivity and anti-convulsant agents. As a part of our research work in the synthesis of pyrimidines containing biological activities, a series of chromenopyrimidine derivatives were synthesized by reaction of an intermediate imine and ammonia derivatives in good to high yields. All synthesized compounds were characterized using IR and NMR (1H and 13C) spectroscopy and elemental analysis data. The antibacterial activity of these compounds was investigated against Staphylococcus aureus (RTCC, 1885), and Escherichia Coli (ATCC, 35922).

 
Keyword(s): IMINE, CHROMENOPYRIMIDINE, PYRANOPYRIMIDINE, ANTIBACTERIAL, MULTICOMPONENT
 
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