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Paper Information

Journal:   JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS)   MARCH 2014 , Volume 19 , Number 3; Page(s) 215 To 220.
 
Paper: 

EFFECTS OF POMEGRANATE JUICE CONSUMPTION ON INFLAMMATORY MARKERS IN PATIENTS WITH TYPE 2 DIABETES: A RANDOMIZED, PLACEBO-CONTROLLED TRIAL

 
 
Author(s):  SOHRAB GOLBON, NASROLLAHZADEH JAVAD, ZAND HAMID, AMIRI ZOHREH, TOHIDI MARYAM*, KIMIAGAR MASOUD
 
* PREVENTION OF METABOLIC DISORDERS RESEARCH CENTER, RESEARCH INSTITUTE FOR ENDOCRINE SCIENCES, SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES, TEHRAN, IRAN
 
Abstract: 

Background: Diabetes causes the increased concentration of circulatory cytokines as a result of inflammation. Considering that pomegranate juice (PJ) is known to have antioxidant and anti-inflammatory properties, the purpose of this study was to determine the effects of PJ consumption on markers of inflammation in patients with type 2 diabetes (T2D).
Materials and Methods: In a randomized, double-blind clinical trial study, 50 patients with T2D (40-65 years old) were randomly assigned to one of two groups. Participants in each group received either 250 mL/day PJ or a control beverage for 12 weeks. Biochemical markers including fasting plasma glucose (FPG), insulin and inflammatory markers were assayed on the baseline and follow-up blood samples.
Results: In all, 44 patients in two groups were included in the analysis: PJ (n=22) and placebo (n=22). After 12 weeks of intervention, in the PJ group, there were 32% and 30% significant decreases in plasma C-reactive protein (hs-CRP) and Interlukin-6, respectively (P<0.05). The mean
±SD plasma interlukin-6 (7.1±5.6 vs. 11.9±14.4 mg/L) and hs-CRP (1791±1657 and 1953±1561 ng/mL) concentrations in the PJ group were significantly lower than the placebo group after intervention (P<0.05).
Conclusion: PJ consumption by patients with T2D does not affect FPG or the insulin resistance index (HOMA-IR), whereas it does reduce Interlukin-6 and hs-CRP concentrations in plasma. Therefore, PJ consumption may have an anti-inflammatory effect in patients with T2D.

 
Keyword(s): DIABETES MELLITUS, INFLAMMATION, POMEGRANATE
 
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