Click for new scientific resources and news about Corona[COVID-19]

Paper Information

Journal:   IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)   2014 , Volume 13 , Number 3; Page(s) 881 To 892.
 
Paper: 

SYNTHESIS AND BIOLOGICAL INVESTIGATION OF SOME NOVEL SULFONAMIDE AND AMIDE DERIVATIVES CONTAINING COUMARIN MOIETIES

 
 
Author(s):  SAEEDI MINA, GOLI FERESHTEH, MAHDAVI MOHAMMAD, DEHGHAN GHOLAMREZA, FARAMARZI MOHAMMAD ALI, FOROUMADI ALIREZA, SHAFIEE ABBAS*
 
* DEPARTMENT OF MEDICINAL CHEMISTRY, FACULTY OF PHARMACY AND PHARMACEUTICAL SCIENCES RESEARCH CENTER, TEHRAN UNIVERSITY OF MEDICINAL SCIENCES, TEHRAN 14176, IRAN
 
Abstract: 

New sulfonamide and amide derivatives containing coumarin moieties; oxo-2H-chromen-sulfamoylphenylacetamides and oxo-2H-chromen-arylacetamides were synthesized starting from diverse 2-chloroacetamide derivatives and a wide range of coumarins. The structures of compounds were elucidated by IR and NMR spectra and also analytical elemental analysis. In the next step, the above mentioned compounds were screened for their antimicrobial and antioxidant activities.
Their antimicrobial activity was assigned using the conventional agar dilution method and the antioxidant activity was assessed using two methods, 1, 1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging method and ferric reducing antioxidant power (FRAP) assay. Although the compounds showed no remarkable antimicrobial activities, most of them exhibited good antioxidant activities. Compounds 5b showed the most potent DPPH activity, whereas 8c wasthe most efficient compound in FRAP assay.

 
Keyword(s): SULFONAMIDES, AMIDES, COUMARINS, ANTIOXIDANT ACTIVITY, ANTIMICROBIAL
 
References: 
  • ندارد
 
  pdf-File tarjomyar Yearly Visit 85
 
Latest on Blog
Enter SID Blog