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Paper Information

Journal:   ARCHIVES OF IRANIAN MEDICINE   FEBRUARY 2013 , Volume 16 , Number 2; Page(s) 93 To 99.
 
Paper: 

DISTRIBUTION OF MYOFIBROBLAST CELLS AND MICROVESSELS AROUND INVASIVE DUCTAL CARCINOMA OF THE BREAST AND COMPARING WITH THE ADJACENT RANGE OF THEIR NORMAL-TO-DCIS ZONES

 
DOI: 

013162/AIM.008

 
Author(s):  DABIRI SHAHRIAR*, TALEBI AMIN, SHAHRYARI JAHANBANOO, SHAMSI MEYMANDI MANZOUMEH, SAFIZADEH HOSSEIN
 
* DEPARTMENT OF PATHOLOGY, AFZALIPOUR MEDICAL SCHOOL, 22 BAHMAN BLVD., KERMAN, IRAN
 
Abstract: 

Background: This study seeks to determine the relationships between manifestation of Myofibroblast in the stroma tissue of hyperplastic pre-invasive breast lesions to invasive cancer by investigating clinicopathological data of patients, their effect on steroid receptor expression and HER2, and angiogenesis according to CD34 antigen expression.
Methods: Handred cases of invasive ductal carcinoma were immunohistochemically investigated for the presence of smooth muscle actin (SMA), ER/PR, HER2, anti-CD34 antibody and microvessel count (MVC). Patients were scored in four different zones of invasive areas: invasive cancer, DCIS, fibrocystic disease±ductal intraepithelial neoplasia (FCD±DIN), and normal tissue.
Results: There was a significant difference in stromal Myofibroblast between all areas except for the stroma of DCIS and FCD±DIN (P<0.001). We observed positive significant correlations between stromal Myofibroblast, HER2 expression, and the numbers of involved lymph nodes in invasive cancer, DCIS, and FCD±DIN (P<0.001). More Myofibroblast were present in grade III cases, with the least frequent observed among grade I cases in the stroma of those with invasive disease, DCIS, and FCD±DIN (P<0.001).
MVC was inversely related to stromal Myofibroblast in invasive cancer (P<0.001) and DCIS (P<0.001), whereas there was a positive correlation in the stroma of FCD±DIN (P=0.002) and normal areas (P=0.054). There was a significant difference in MVC observed in all areas except for DCIS and FCD±DIN (P<0.001). We noted significant inverse correlations between MVC, HER2 expression, and the numbers of involved lymph nodes in invasive cancer and DCIS (P<0.001). Most MVC were present in grade I, with the least frequent observed in grade III cases in the stroma of invasive cancer, DCIS and FCD±DIN (P<0.001).
Conclusion: Angiogenesis can be observed before any significant myofibroblastic changes in the pre-invasive breast lesions. The elevated content of Myofibroblast in stroma of tumor; probably may be a worse prognostic factor and the steps from atypical epithelial hyperplasia to DCIS and then to the invasive carcinoma do not appear to be always part of a linear progression.

 
Keyword(s): ANGIOGENESIS, CD34, ER/PR, HER2, MYOFIBROBLAST
 
References: 
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