SID.ir New Version

Paper Information

Journal:   ARCHIVES OF IRANIAN MEDICINE   FEBRUARY 2013 , Volume 16 , Number 2; Page(s) 93 To 99.
 
Paper: 

Distribution Of Myofibroblast Cells And Microvessels Around Invasive Ductal Carcinoma Of The Breast And Comparing With The Adjacent Range Of Their Normal-To-Dcis Zones

 
DOI: 

013162/AIM.008

 
Author(s):  Dabiri Shahriar*, Talebi Amin, Shahryari Jahanbanoo, Shamsi Meymandi Manzoumeh, Safizadeh Hossein
 
* DEPARTMENT OF PATHOLOGY, AFZALIPOUR MEDICAL SCHOOL, 22 BAHMAN BLVD., KERMAN, IRAN
 
Abstract: 
Background: This study seeks to determine the relationships between manifestation of Myofibroblast in the stroma tissue of hyperplastic pre-invasive breast lesions to invasive cancer by investigating clinicopathological data of patients, their effect on steroid receptor expression and HER2, and angiogenesis according to CD34 antigen expression.Methods: Handred cases of invasive ductal carcinoma were immunohistochemically investigated for the presence of smooth muscle actin (SMA), ER/PR, HER2, anti-CD34 antibody and microvessel count (MVC). Patients were scored in four different zones of invasive areas: invasive cancer, DCIS, fibrocystic disease±ductal intraepithelial neoplasia (FCD±DIN), and normal tissue.Results: There was a significant difference in stromal Myofibroblast between all areas except for the stroma of DCIS and FCD±DIN (P<0.001). We observed positive significant correlations between stromal Myofibroblast, HER2 expression, and the numbers of involved lymph nodes in invasive cancer, DCIS, and FCD±DIN (P<0.001). More Myofibroblast were present in grade III cases, with the least frequent observed among grade I cases in the stroma of those with invasive disease, DCIS, and FCD±DIN (P<0.001).MVC was inversely related to stromal Myofibroblast in invasive cancer (P<0.001) and DCIS (P<0.001), whereas there was a positive correlation in the stroma of FCD±DIN (P=0.002) and normal areas (P=0.054). There was a significant difference in MVC observed in all areas except for DCIS and FCD±DIN (P<0.001). We noted significant inverse correlations between MVC, HER2 expression, and the numbers of involved lymph nodes in invasive cancer and DCIS (P<0.001). Most MVC were present in grade I, with the least frequent observed in grade III cases in the stroma of invasive cancer, DCIS and FCD±DIN (P<0.001).Conclusion: Angiogenesis can be observed before any significant myofibroblastic changes in the pre-invasive breast lesions. The elevated content of Myofibroblast in stroma of tumor; probably may be a worse prognostic factor and the steps from atypical epithelial hyperplasia to DCIS and then to the invasive carcinoma do not appear to be always part of a linear progression.
 
Keyword(s): ANGIOGENESIS, CD34, ER/PR, HER2, MYOFIBROBLAST
 
 
International related papers: 
 
Most related Highly related Moderately related Least related
 
References: 
  • Not Registered.
  •  
  •  
 
Citations: 
  • Not Registered.
 
+ Click to Cite.
APA: Copy

DABIRI, S., & TALEBI, A., & SHAHRYARI, J., & SHAMSI MEYMANDI, M., & SAFIZADEH, H. (2013). DISTRIBUTION OF MYOFIBROBLAST CELLS AND MICROVESSELS AROUND INVASIVE DUCTAL CARCINOMA OF THE BREAST AND COMPARING WITH THE ADJACENT RANGE OF THEIR NORMAL-TO-DCIS ZONES. ARCHIVES OF IRANIAN MEDICINE, 16(2), 93-99. https://www.sid.ir/en/journal/ViewPaper.aspx?id=409309



Vancouver: Copy

DABIRI SHAHRIAR, TALEBI AMIN, SHAHRYARI JAHANBANOO, SHAMSI MEYMANDI MANZOUMEH, SAFIZADEH HOSSEIN. DISTRIBUTION OF MYOFIBROBLAST CELLS AND MICROVESSELS AROUND INVASIVE DUCTAL CARCINOMA OF THE BREAST AND COMPARING WITH THE ADJACENT RANGE OF THEIR NORMAL-TO-DCIS ZONES. ARCHIVES OF IRANIAN MEDICINE. 2013 [cited 2022May21];16(2):93-99. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=409309



IEEE: Copy

DABIRI, S., TALEBI, A., SHAHRYARI, J., SHAMSI MEYMANDI, M., SAFIZADEH, H., 2013. DISTRIBUTION OF MYOFIBROBLAST CELLS AND MICROVESSELS AROUND INVASIVE DUCTAL CARCINOMA OF THE BREAST AND COMPARING WITH THE ADJACENT RANGE OF THEIR NORMAL-TO-DCIS ZONES. ARCHIVES OF IRANIAN MEDICINE, [online] 16(2), pp.93-99. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=409309.



 
  pdf-File
Yearly Visit 55
 
 
Latest on Blog
Enter SID Blog