Paper Information

Journal:   JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS)   APRIL 2014 , Volume 19 , Number 4; Page(s) 287 To 292.
 
Paper: 

THE EFFECT OF SALSALATE ON BIOCHEMICAL FACTORS AND ENDOTHELIAL DYSFUNCTION OF PREDIABETIC PATIENTS: A RANDOMIZED CLINICAL TRIAL

 
 
Author(s):  FAKHRI MARYAM, FAGHIH IMANI ELHAM, KHALILI NOUSHIN*
 
* DEPARTMENT OF INTERNAL MEDICINE, AL-ZAHRA HOSPITAL, ISFAHAN ENDOCRINE AND METABOLISM RESEARCH CENTER, ISFAHAN UNIVERSITY OF MEDICAL SCIENCES, ISFAHAN, IRAN
 
Abstract: 

Background: The beneficial effect of using nonacetylated salicylates such as salsalate on decreasing the speed of diabetes progression is a controversial issue. The aim of this study was to evaluate the effect of salsalate on metabolic-syndrome-associated parameters as well as the endothelial function of diabetic and impaired glucose tolerance patients.
Materials and Methods: Patients were collected from Isfahan endocrinology research center referrals. Patients with impaired glucose tolerance diagnosis or newly diagnosed diabetes were enrolled in the study. Patients were randomized to receive 1.5 g salsalate (2×750 mg) BID or placebo twice a day for 3 months. After the mentioned period, all patients were recalled and complete examination was done; blood samples for biochemistry measurements were drawn (for measuring FBS, post prandial glucose, HbA1C, Total cholesterol, HDL, TG, LDL) and forearm flow-mediated dilation (FMD) was performed.
Results: Forty patients were enrolled, 32 patients (80%) were female. Mean age of patients was 47.15
±6.67 years. FBS (fasting blood sugar) was shown to be significantly different between intervention and control subjects before or after treatment. FMD increased significantly in the intervention group (P=0.004). Conclusion: The study showed that salsalate decreased FBS levels of patients. It may also improve endothelial function as FMD increased significantly in the intervention group.

 
Keyword(s): DIABETES, ENDOTHELIAL FUNCTION, SALSALATE
 
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