Paper Information

Journal:   ARCHIVES OF IRANIAN MEDICINE   FEBRUARY 2013 , Volume 16 , Number 2; Page(s) 74 To 77.
 
Paper: 

PRELIMINARY STUDY OF THE LEVEL OF VISFATIN AND THE RELATIONSHIP WITH INSULIN RESISTANCE IN CHINESE PATIENTS WITH CHRONIC HEPATITIS C

 
DOI: 

013162/AIM.005

 
Author(s):  WANG YUMING*, CHEN JIE, PAN JINGYE, ZHANG WENHUI, CHEN ZENGQIANG, YU FANGYU
 
* DEPARTMENT OF LABORATORY MEDICINE, THE FIRST AFFILIATED HOSPITAL OF WENZHOU MEDICAL COLLEGE, WENZHOU CHINA
 
Abstract: 

Background: Many studies have suggested that visfatin expression is closely related to the occurrence of insulin resistance (IR), while the precise role of visfatin in the regulation of IR in chronic hepatitis C (CHC) is not clear.
Methods: We investigated fasting glucose, fasting insulin (FINS), C peptide, visfatin, visfatin mRNA, interleukin (IL) -6, tumor necrosis factor (TNF) -
a, C-reactive protein (CRP) and other parameters of 315 patients with CHC and 150 control cases in China. Meanwhile we collected clinical and other laboratory data for further analysis.
Results: Compared with the control group, the CHC group had a significant increase in alanine aminotransferase (ALT), aspartate aminotransferase (AST), the AST to platelet ratio index (APRI), ratio of AST to ALT (AAR), gammaglutamyl trans-peptidase, IL-6, TNF-
a, visfatin, visfatin mRNA, FINS, fasting C peptide, and IR index. The visfatin, visfatin mRNA, insulin, IR index, Homa b cell function index (HBCI), and fasting b-cell function index (FBCI) of the subjects with high body mass index (BMI) from the CHC sub-group were significantly higher than the normal BMI sub-group of CHC patients. We found a positive correlation between visfatin, visfatin mRNA and BMI, IL-6, TNF-a, and IR index.
Conclusion: Our data suggest that visfatin may be related to IR in Chinese CHC patients.

 
Keyword(s): CHRONIC HEPATITIS C, INSULIN RESISTANCE, LIVER, VISFATIN
 
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