Click for new scientific resources and news about Corona[COVID-19]

Paper Information

Journal:   IRANIAN JOURNAL OF CHILD NEUROLOGY (IJCN)   SPRING 2013 , Volume 7 , Number 2; Page(s) 37 To 42.
 
Paper: 

ZONISAMIDE EFFICACY AS ADJUNCTIVE THERAPY IN CHILDREN WITH REFRACTORY EPILEPSY

 
 
Author(s):  KARIMZADEH PARVANEH, ASHRAFI MAHMOUD REZA, BAKHSHANDEHBALI MOHAMMAD KAZEM*, NASEHI MOHAMMAD MAHDI, TAHERIOTAGHSARA SEYEDEH MOHADESEH, TAGHDIRI MOHAMMAD MAHDI, GHOFRANI MOHAMMAD
 
* PEDIATRIC RESEARCH CENTER, SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES (SBMU), TEHRAN, IRAN
 
Abstract: 

Objective:
Approximately one third of epileptic children do not achieve complete seizure improvement. Zonisamide is a new antiepileptic drug which is effective as adjunctive therapy in treatment of intractable partial seizures. The purpose of the current study was to evaluate the effectiveness, safety, and tolerability of Zonisamide in epileptic children.
Materials
d Methods:
From November 2011 until October 2012, 68 children who referred to Children’s Medical Center and Mofid Children Hospital due to refractory epilepsy (failure of seizure control with the use of two or more anticonvulsant drugs) entered the study. The patients were treated with Zonisamide by dose of 2- 12 mg/kg daily in addition to the previous medication. We followed the children every three to four-weeks intervals based on daily frequency, severity and duration of seizures. During the follow-up equal and more than fifty percent reduction in seizure frequency or severity known as response to the drug.
Results:
In this study 68 patients were examined that 61 children reached the last stage.35 (57.4%) were male and 26 (42.6%) patients were female. After first and six months of Zonisamide administration daily seizure frequency decreased to 2.95±3.54 and 3.73±3.5 respectively. There was significant difference between seizure frequency in first and six month after Zonisamide toward initial attacks. After six months ZNS therapy a little side effects were created in 10 patients (16.4%) including stuttering(4.9%), decreased appetite (4.9%), hallucination (1.6%), dizziness(1.6%), blurred vision(1.6%) and suspiring(1.6%) as all of them eliminated later dosage reduction.
Conclusion:
This study con?rms the short term ef?cacy and safety of Zonisamide in children with refractory epilepsies.

 
Keyword(s): INTRACTABLE EPILEPSY, ANTIEPILEPTIC DRUGS, ZONISAMIDE
 
 
References: 
  • Not Registered.
  •  
  •  
 
Citations: 
  • Not Registered.
 
+ Click to Cite.
APA: Copy

KARIMZADEH, P., & ASHRAFI, M., & BAKHSHANDEHBALI, M., & NASEHI, M., & TAHERIOTAGHSARA, S., & TAGHDIRI, M., & GHOFRANI, M. (2013). ZONISAMIDE EFFICACY AS ADJUNCTIVE THERAPY IN CHILDREN WITH REFRACTORY EPILEPSY. IRANIAN JOURNAL OF CHILD NEUROLOGY (IJCN), 7(2), 37-42. https://www.sid.ir/en/journal/ViewPaper.aspx?id=409245



Vancouver: Copy

KARIMZADEH PARVANEH, ASHRAFI MAHMOUD REZA, BAKHSHANDEHBALI MOHAMMAD KAZEM, NASEHI MOHAMMAD MAHDI, TAHERIOTAGHSARA SEYEDEH MOHADESEH, TAGHDIRI MOHAMMAD MAHDI, GHOFRANI MOHAMMAD. ZONISAMIDE EFFICACY AS ADJUNCTIVE THERAPY IN CHILDREN WITH REFRACTORY EPILEPSY. IRANIAN JOURNAL OF CHILD NEUROLOGY (IJCN). 2013 [cited 2021October16];7(2):37-42. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=409245



IEEE: Copy

KARIMZADEH, P., ASHRAFI, M., BAKHSHANDEHBALI, M., NASEHI, M., TAHERIOTAGHSARA, S., TAGHDIRI, M., GHOFRANI, M., 2013. ZONISAMIDE EFFICACY AS ADJUNCTIVE THERAPY IN CHILDREN WITH REFRACTORY EPILEPSY. IRANIAN JOURNAL OF CHILD NEUROLOGY (IJCN), [online] 7(2), pp.37-42. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=409245.



 
  pdf-File
Yearly Visit 42
 
 
Latest on Blog
Enter SID Blog