Paper Information

Journal:   IRANIAN JOURNAL OF ARTHROPOD-BORNE DISEASES   JUNE 2015 , Volume 9 , Number 1; Page(s) 104 To 115.
 
Paper: 

BIOLOGICAL ACTIVITIES AND COMPOSITION OF FERULAGO CARDUCHORUM ESSENTIAL OIL

 
 
Author(s):  GOL FAKHRABADI FERESHTEH, KHANAVI MAHNAZ, OSTAD SEYED NASSER, SAEIDNIA SOODABEH, VATANDOOST HASSAN, ABAI MOHAMMAD REZA, HAFIZI MITRA, YOUSEFBEYK FATEMEH, RAZZAGHI RAD YAGHOOB, BAGHENEGADIAN AMENEH, SHAMS ARDEKANI MOHAMMAD REZA
 
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Abstract: 

Background: Ferulago carduchorum Boiss and Hausskn belongs to the Apiaceae family. This plant grows in west part of Iran that local people added it to dairy and oil ghee to delay expiration date and give them a pleasant taste.
The aim of this study was to investigate the antioxidant, antimicrobial, acetyl cholinesterase inhibition, cytotoxic, larvicidal activities and composition of essential oil of F. carduchorum.
Methods: Acetyl cholinesterase (AChE) inhibitory, larvicidal activities and chemical composition of essential oil of F. carduchorumwere investigated. Besides, antioxidant, antimicrobial and cytotoxic activities of essential oil were tested using DPPH, microdilution method and MTT assay, respectively.
Results: The major components of essential oil were (z) -
b -ocimene (43.3%), a-pinene (18.23%) and bornyl acetate (3.98%). Among 43 identified components, monoterpenes were the most compounds (84.63%). The essential oil had noticeable efficiency against Candida albicans (MIC=2340 ?g ml-1) and it was effective against Anopheles stephensiwith LC50 and LC90 values of 12.78 and 47.43 ppm, respectively. The essential oil could inhibit AChE (IC50=23.6 ml ml-1). The essential oil showed high cytotoxicity on T47D, HEP-G2 and HT-29 cell lines (IC50<2 mg ml-1).
Conclusion: The essential oil of F. carduchorum collected from west of Iran had anti- Candida, larvicidal and cytotoxicity effects and should be further investigated in othersin vitro and in vivo experimental models.

 
Keyword(s): FERULAGO CARDUCHORUM, ESSENTIAL OIL, ANTIMICROBIAL, ANTIACETYL CHOLINESTERASE, LARVICIDAL ACTIVITY
 
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