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Journal:   JOURNAL OF ARTHROPOD-BORNE DISEASES   JUNE 2015 , Volume 9 , Number 1; Page(s) 71 To 83.
 
Paper: 

Resistance Mechanisms Of Anopheles Stephensi (Diptera: Culicidae) To Temephos
 
 
Author(s):  Soltani Abouzar, Vatandoost Hassan*, Oshaghi Mohammad Ali*, Maleki Ravasan Nase, Enayati Ahmad Ali, Asgarian Fatemeh
 
* DEPARTMENT OF MEDICAL ENTOMOLOGY AND VECTOR CONTROL, SCHOOL OF PUBLIC HEALTH AND NATIONAL INSTITUTE OF HEALTH RESEARCH, TEHRAN UNIVERSITY OF MEDICAL SCIENCES, TEHRAN, IRAN
 
Abstract: 
Background: Anopheles stephensi is a sub-tropical species and has been considered as one of the most important vector of human malaria throughout the Middle East and South Asian region including the malarious areas of southern Iran. Current reports confirmed An. stephensi resistance to temephos in Oman and India. However, there is no comprehensive research on mechanisms of temephos resistance in An. stephensi in the literature. This study was designed in order to clarify the enzymatic and molecular mechanisms of temephos resistance in this species.Methods: Profile activities of a- and b-esterases, mixed function oxidase (MFO), glutathione-S-transferase (GST), insensitive acetylcholinesterase, and para-nitrophenyl acetate (PNPA) -esterase enzymes were tested forAn. stephensi strain with resistance ratio of 15.82 to temephos in comparison with susceptible strain.Results: Results showed that the mean activity of ?-EST, GST and AChE enzymes were classified as altered indicating metabolic mechanisms have considerable role in resistance of An. stephensi to temephos. Molecular study using PCR-RFLP method to trace the G119S mutation in ACE-1 gene showed lack of the mutation responsible for organophosphate insecticide resistance in the temephos-selected strain of An. stephensi.Conclusion: This study showed that the altered enzymes but not targets site insensitivity of ACE-1 are responsible for temephos resistance in An. stephensi in south of Iran.
 
Keyword(s): ANOPHELES STEPHENSI, TEMEPHOS, MECHANISMS OF RESISTANCE, ACETYLCHOLINESTERASE GENE, MALARIA
 
 
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APA: Copy

SOLTANI, A., & VATANDOOST, H., & OSHAGHI, M., & MALEKI RAVASAN, N., & ENAYATI, A., & ASGARIAN, F. (2015). RESISTANCE MECHANISMS OF ANOPHELES STEPHENSI (DIPTERA: CULICIDAE) TO TEMEPHOS. JOURNAL OF ARTHROPOD-BORNE DISEASES, 9(1), 71-83. https://www.sid.ir/en/journal/ViewPaper.aspx?id=409196



Vancouver: Copy

SOLTANI ABOUZAR, VATANDOOST HASSAN, OSHAGHI MOHAMMAD ALI, MALEKI RAVASAN NASE, ENAYATI AHMAD ALI, ASGARIAN FATEMEH. RESISTANCE MECHANISMS OF ANOPHELES STEPHENSI (DIPTERA: CULICIDAE) TO TEMEPHOS. JOURNAL OF ARTHROPOD-BORNE DISEASES. 2015 [cited 2022June30];9(1):71-83. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=409196



IEEE: Copy

SOLTANI, A., VATANDOOST, H., OSHAGHI, M., MALEKI RAVASAN, N., ENAYATI, A., ASGARIAN, F., 2015. RESISTANCE MECHANISMS OF ANOPHELES STEPHENSI (DIPTERA: CULICIDAE) TO TEMEPHOS. JOURNAL OF ARTHROPOD-BORNE DISEASES, [online] 9(1), pp.71-83. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=409196.
 
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