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Paper Information

Journal:   IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ)   JUNE 2014 , Volume 16 , Number 6; Page(s) 1 To 7.
 
Paper: 

CROSS-TALK BETWEEN ENDOTHELIN-1 AND MINERAL METABOLISM IN HEMODIALYSIS PATIENTS: A CROSS-SECTIONAL STUDY

 
 
Author(s):  HALAJ ZADEH JAMAL, GHORBANIHAGHJO AMIR*, RASHTCHIZADEH NADEREH, ARGANI HASSAN, VALIZADEH SHAHNAM, HALAJ NAJAT, VATANKHAH AMIR MANSOUR
 
* UROLOGY AND NEPHROLOGY RESEARCH CENTER, SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES, TEHRAN, IR IRAN
 
Abstract: 

Background: Endotheline-1 (ET-1), an endothelial mediator, influences on mineral metabolism; especially vascular calcification in uremic patients.
Objectives: The aim of the present study was to evaluate of ET-1, high-sensitivity C-reactive protein (hs-CRP) and mineral metabolites as the main factors for vascular calcification and inflammation in hemodialysis (HD) patients.
Patients and Methods: In this cross-sectional study, 46 chronic stable HD patients were selected from nephrology departments of Tabriz University of Medical Sciences affiliated hospitals and classified based on phosphorus (P), Ca-P product (Ca × P) and intact Parathyroid Hormone (iPTH) levels. We evaluated fasting serum ET-1and hs-CRP levels by the standard methods and compared with 46 healthy control subjects.
Results: The levels of serum hs-CRP and ET-1 were significantly higher in the patient’s group compared with controls (4.40±1.26 vs. 1.38±1.61, P
<0.0001, and 2.31±0.87 vs. 0.75±0.48, P<0.0001, respectively) and with regard to Ca × P product cut-off point (3.99±0.78 vs. 5.33±1.64, P<0.0001, and 2±0.73 vs. 3.04±0.73, P<0.0001 respectively). ET-1 was correlated significantly with hs-CRP level (r=0.776, P<0.0001). Serum P, Ca × P and iPTH levels directly and Ca indirectly were correlated with serum ET-1 in HD patients (r=0.932, P<0.0001, r=0.766, P<0.0001, r=0.514, P<0.0001, r=-0.538, P<0.0001 respectively). Multiple regression analysis demonstrated that serum P were independently associated with ET-1 levels (b=0.932, P<0.0001).
Conclusions: Serum P and iPTH levels were independently associated with ET-1 and those may play a role in development of endothelial dysfunction in chronic kidney disease.

 
Keyword(s): HEMODIALYSIS, PARATHYROID HORMONE, ENDOTHELIN-1
 
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