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Paper Information

Journal:   IRANIAN JOURNAL OF PATHOLOGY (IJP)   SUMMER 2014 , Volume 9 , Number 3; Page(s) 189 To 194.
 
Paper: 

HEPATITIS B INFECTION: PREVALENCE AND RESPONSE TO VACCINATION AMONG HEALTH CARE WORKERS IN BABOL, NORTHERN IRAN

 
 
Author(s):  BAYANI MASOMEH, SIADATI SEPIDEH*, HAJIAHMADI MAHMOUD, KHANI AFSHIN, NAEMI NAVID
 
* DEPARTMENT OF PATHOLOGY, BABOL UNIVERSITY OF MEDICAL SCIENCES, BABOL, IRAN
 
Abstract: 

Background & Objectives: Hepatitis B is one of the major health problems in the world. Health care workers (HCWs) are at high risk of acquiring hepatitis B virus. The aim of this study was to evaluate the prevalence of HBV infection and the immune response to HBV vaccine among the HCWs in Babol, northern Iran.
Methods: This study was accomplished on 527 HCWs and administrative staff working at Rohani Hospital, Babol, northern Iran from 2011 to 2012. HBs- Ag, HBc- Ab and HBs- Ab were measured by ELISA method. All susceptible staff vaccinated with recombinant hepatitis B vaccine (Pasteur Institute of Iran) and HBs-Ab titer was evaluated 3 months after the last dose.
Results: Anti-HBc was positive in 32 (6.1%) and HBs-Ag in 4 (0.75%) of the participants. The HBV exposure in HCWs was four times greater than the administrative staff (6.65% vs.1.63%). There was significant association between HBV exposure and occupation and also educational level (P<0.001), however, this association was not found with age and gender. Seroconversion was seen in 211 (91.7%) of 230 participants who received three-dose series of hepatitis B vaccine. The seroconversion is significantly decreasing by the increase of age (P<0.001), however, no significant association was seen with age and gender.
Conclusion: Considering high HBV infection exposure in HCWs, it is mandatory to ensure vaccination program and postvaccination evaluation along with education and safe work environment preparation.

 
Keyword(s): HEPATITIS B, HEALTH PERSONNEL, VACCINATION
 
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