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Paper Information

Journal:   IRANIAN JOURNAL OF KIDNEY DISEASES (IJKD)   MAY 2014 , Volume 8 , Number 3; Page(s) 252 To 256.
 
Paper: 

PRE-UREMIC CALCIPHYLAXIS (CASE REPORT)

 
 
Author(s):  NAYER ALI*, VIRMANI SHARAD, GONZALEZ SUAREZ MARIA, GOEZ GUTIERREZ ELVIA, ROSENBERG ANDREW E., SALMAN LOAY, ASIF ARIF
 
* DIVISION OF NEPHROLOGY AND HYPERTENSION, UNIVERSITY OF MIAMI, CLINICAL RESEARCH BUILDING, SUITE 825, 1120 NW 14TH ST., MIAMI, FL 33136, USA
 
Abstract: 

Calciphylaxis is characterized by calcification and thrombosis of arteries resulting in ischemic necrosis of predominantly skin and subcutaneous tissue. Primarily affecting patients with end-stage renal disease, calciphylaxis is diagnosed rarely in the absence of renal replacement therapy. We report an elderly obese woman presented with leg pain and ulceration. She had chronic kidney disease, diabetes mellitus, hypertension, and peripheral vascular disease. Angiography revealed occlusion of the left superficial femoral, popliteal, and distal tibial arteries. Amputation was performed. Histological examination demonstrated medial calcification, intimal hyperplasia, and thrombosis of small- and medium-sized arteries in the subcutaneous tissue. This case features calciphylaxis in a patient with chronic kidney disease before the onset of uremia. Calciphylaxis and atherosclerotic peripheral vascular disease have several risk factors in common. This report calls attention to a disorder that can be masqueraded as leg ulceration due to peripheral vascular disease in the absence of renal replacement therapy.

 
Keyword(s): CALCIPHYLAXIS, PERIPHERAL VASCULAR DISEASE, LEG ULCERATION, CHRONIC KIDNEY DISEASE
 
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