Paper Information

Journal:   ADVANCED PHARMACEUTICAL BULLETIN   2013 , Volume 3 , Number 2; Page(s) 453 To 455.
 
Paper: 

IN VITRO CYTOTOXIC ACTIVITY OF FOUR PLANTS USED IN PERSIAN TRADITIONAL MEDICINE

 
Author(s):  ZARE SHAHNEH FATEMEH, BARADARAN BEHZAD*, ORANGI MONA, ZAMANI FATEMEH
 
* IMMUNOLOGY RESEARCH CENTER (IRC), TABRIZ UNIVERSITY OF MEDICAL SCIENCES, TABRIZ, IRAN
 
Abstract: 

Purpose: The aim of this study was to investigate in vitro cytotoxic activity of four methanolic crude plant extracts against panel cell lines.
Methods: Methanolic extracts were tested for their possible antitumor activity and cytotoxicity using the 3- (4, 5-dimetylthiazol-2-yl) -2, 5- diphenyltetrazolium bromide (MTT) assay on six cancer cell lines; non-Hodgkin’s B-cell lymphoma (Raji), human leukemic monocyte lymphoma (U937), human acute myelocytic leukemia (KG-1A), human breast carcinoma (MCF-7 cells), human Prostate Cancer (PC3) and mouse fibrosarcoma (WEHI-164) cell lines and one normal cell line; Human Umbilical Vein Endothelial Cells (HUVEC).
Results: All species showed dose dependent inhibition of cell proliferation. IC50 values ranging from 25.66±1.2 to 205.11±1.3
mg/ml. The highest cytotoxic activity Chelidonium majus L>Ferulago Angulata DC>Echinophora platyloba DC>Salvia officinalis L, respectively.
Conclusion: all extracts demonstrate promising cytotoxicity activity as a natural resource for future bio-guided fractionation and isolation of potential antitumor agents.

 
Keyword(s): CYTOTOXIC, ANTI-TUMOR, APOPTOSIS, CANCER
 
References: 
  • ندارد
 
  pdf-File tarjomyar Yearly Visit 72
 
Latest on Blog
Enter SID Blog