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Paper Information

Journal:   ADVANCED PHARMACEUTICAL BULLETIN   2013 , Volume 3 , Number 2; Page(s) 443 To 446.
 
Paper: 

HLA-G EXPRESSION PATTERN: RELIABLE ASSESSMENT FOR PREGNANCY OUTCOME PREDICTION

 
 
Author(s):  MOSAFERI ELNAZ, MAJIDI JAFAR, MOHAMMADIAN MOZHDEH, BABALOO ZOHREH, MONFAREDAN AMIR, BARADARAN BEHZAD*
 
* FACULTY OF MEDICINE AND IMMUNOLOGY RESEARCH CENTER, TABRIZ UNIVERSITY OF MEDICAL SCIENCES, TABRIZ, IRAN
 
Abstract: 

Because mothers and fathers are more or less dissimilar at multiple HLA loci, mother considers her fetus as a semi-allograft. Mother's immune system may recognize paternal HLA as foreign antigen and may develop anti-paternal HLA antibodies and cytotoxic T lymphocyte. There are some mechanisms that modulate maternal immune responses during pregnancy, in order to make uterus an immune privileged site. This immunosuppression is believed to be mediated, at least partly, by HLA-G, non-classical class I human leukocyte antigen (HLA) molecule that is strongly expressed in cytotrophoblast and placenta. The major HLA-G function is its ability to inhibit T and B lymphocytes, NK cells and antigen-presenting cells (APC).Since HLA-G is expressed strongly at the maternofetal interface and has an essential role in immunosuppression, HLA-G polymorphism and altered expression of HLA-G seems to be associated with some complications of pregnancy, such as pre-eclampsia, recurrent misscariage and failure in IVF.This perspective discusses recent findings about HLA-G genetics, function, expression and polymorphism; and focus on HLA-G role in the etiology of recurrent miscarriage.

 
Keyword(s): HLA-G, PLACENTA, RECURRENT MISCARRIAGE
 
 
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APA: Copy

MOSAFERI, E., & MAJIDI, J., & MOHAMMADIAN, M., & BABALOO, Z., & MONFAREDAN, A., & BARADARAN, B. (2013). HLA-G EXPRESSION PATTERN: RELIABLE ASSESSMENT FOR PREGNANCY OUTCOME PREDICTION. ADVANCED PHARMACEUTICAL BULLETIN, 3(2), 443-446. https://www.sid.ir/en/journal/ViewPaper.aspx?id=409035



Vancouver: Copy

MOSAFERI ELNAZ, MAJIDI JAFAR, MOHAMMADIAN MOZHDEH, BABALOO ZOHREH, MONFAREDAN AMIR, BARADARAN BEHZAD. HLA-G EXPRESSION PATTERN: RELIABLE ASSESSMENT FOR PREGNANCY OUTCOME PREDICTION. ADVANCED PHARMACEUTICAL BULLETIN. 2013 [cited 2021November27];3(2):443-446. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=409035



IEEE: Copy

MOSAFERI, E., MAJIDI, J., MOHAMMADIAN, M., BABALOO, Z., MONFAREDAN, A., BARADARAN, B., 2013. HLA-G EXPRESSION PATTERN: RELIABLE ASSESSMENT FOR PREGNANCY OUTCOME PREDICTION. ADVANCED PHARMACEUTICAL BULLETIN, [online] 3(2), pp.443-446. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=409035.



 
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