Paper Information

Journal:   IRANIAN JOURNAL OF CHILD NEUROLOGY (IJCN)   WINTER 2013 , Volume 7 , Number 1; Page(s) 9 To 14.
 
Paper: 

PROPHYLAXIS OF CHILDHOOD MIGRAINE: TOPIRAMATE VERSUS PROPRANOLOL

 
 
Author(s):  TONEKABONI SEYED HASSAN, GHAZAVI AHAD, FAYYAZI AFSHIN*, KHAJEH ALI, TAGHDIRI MOHAMMAD MAHDI, ABDOLLAH GORJI FATEMEH, AZARGHASHB EZNOLLAH
 
* PEDIATRIC NEUROLOGY RESEARCH CENTER, HAMADAN UNIVERSITY OF MEDICAL SCIENCES, HAMADAN, IRAN
 
Abstract: 

Objective:
Headache is a common disabling neurological disorder and migraine comprises more than half the causes of recurrent headaches in children. Despite extended prevalence of this type of headache there is lack of evidence about best drug treatment for migraine. So we aimed to compare the therapeutic effects of these drugs on childhood migraine.
Materials
d Methods:
In the current study, a randomized clinical trial consisting of 78 patients according to 2004 International Headache Association criteria were randomly assigned to two groups that matched by age and sex. One of these two groups was treated with Topiramate, while the other was given Propranolol. After one and four months, the efficiency of these treatments was measured in terms of frequency, severity and duration of migraine attacks.
Results:
Results obtained from the data collected showed that of these 78 studied patients, 38 patients received Topiramate treatment (group A) and the rest (40 patients; group B) was treated with Propranolol. The average age of group A was 8.5
±2.9 years and that of group B was 8.3±2.8 years. No significant difference was observed between these two groups in terms of reduction in frequency, severity and duration of migraine attacks.
Conclusion:
Results showed that both treatments had the same efficiency in healing migraine headaches and there was no significant difference between their treating results. However, further studies are needed to examine medical effects of these two medicines.

 
Keyword(s): MIGRAINE, CHILDREN, PROPRANOLOL, TOPIRAMATE
 
References: 
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