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Paper Information

Journal:   IRANIAN JOURNAL OF CHILD NEUROLOGY (IJCN)   FALL 2013 , Volume 7 , Number 4; Page(s) 7 To 11.
 
Paper: 

THE EFFICACY AND SAFETY OF TOPIRAMATE FOR PROPHYLAXIS OF MIGRAINE IN CHILDREN

 
 
Author(s):  FALLAH RAZIEH, AKHAVAN KARBASI SEDIGHAH*, SHAJARI AHMAD, FROMANDI MOSTAFA
 
* SHAHID SADOUGHI HOSPITAL, AVE - SINA BLVD, SHAHID GHANDI BLVD, YAZD, IRAN
 
Abstract: 

Objective Migraine is the most common acute intermittent primary headache in children and prophylactic therapy is indicated in children with frequent or disabling headaches. The purpose of this study was to evaluate the efficacy and safety of topiramate (TPM) for migraine prophylaxis in children.
Materials
&Methods In a quasi-experimental study, monthly frequency, severity and duration of headache, migraine disability, and side-effects were evaluated in 100 children who were referred to the Pediatric Neurology Clinic of Shahid Sadoughi University of Medical Sciences, Yazd, Iran from April 2011 to March 2012, and were treated with 3 mg/kg/day of TPM for three months.
Results Fifty eight (57.4%) girls and 42 (41.6%) boys with the mean age of 10.46
±2.11 years were evaluated. Monthly frequency, severity, and duration of headache decreased with treatment from 15.34±7.28 to 6.07±3.16 attacks, from 6.21±1.74 to 3.15±2.22, and from 2.28±1.55 to 0.94±0.35 hours, respectively, and the Pediatric Migraine Disability Assessment score reduced with TPM from 32.48±9.33 to 15.54±6.16. Transient side-effects were seen in 21% of the patients, including hyperthermia in 11%, anorexia and weight loss in 6%, and drowsiness in 4%. No serious side-effects were reported.
Conclusion TPM could be considered as a safe and effective drug in pediatric migraine prophylaxis.

 
Keyword(s): HEADACHE, MIGRAINE, PROPHYLAXIS, TOPIRAMATE
 
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