Click for new scientific resources and news about Corona[COVID-19]

Paper Information

Journal:   ADVANCED PHARMACEUTICAL BULLETIN   2013 , Volume 3 , Number 2; Page(s) 295 To 301.
 
Paper: 

PERCUTANEOUS ABSORPTION OF SALICYLIC ACID AFTER ADMINISTRATION OF TROLAMINE SALICYLATE CREAM IN RATS WITH TRANSCUTOL ® AND EUCALYPTUS OIL PRE-TREATED SKIN

 
 
Author(s):  SAJJADI PANIZ, KHODAYAR MOHAMMAD JAVAD, SHARIF MAKHMALZADEH BEHZAD, REZAEE SAEED*
 
* DEPARTMENT OF PHARMACEUTICS, SCHOOL OF PHARMACY, AHVAZ JUNDISHAPUR UNIVERSITY OF MEDICAL SCIENCES, AHVAZ, IRAN
 
Abstract: 

Purpose: This study was conducted to assess the effect of skin pre-treatment with Transcutol? and eucalyptus oil on systemic absorption of topical trolamine salicylate in rat.
Methods: Pharmacokinetic parameters of salicylic acid following administration of trolamine salicylate on rat skin pre-treated with either Transcutol
? or eucalyptus oil were determined using both non-compartmental and non-linear mixed effect modeling approaches and compared with those of control group.
Results: Median (% of interquartile range/median) of salicylic acid AUC0-8hr (ng/mL/hr) values in Transcutol
? or eucalyptus oil treated rats were 2522 (139%) and 58976 (141%), respectively as compared to the 3023 (327%) of the control group. Skin pre-treatment with eucalyptus oil could significantly decrease extravascular volume of distribution (V/F) and elimination rate constant (k) of salicylic acid.
Conclusion: Unlike Transcutol
?, eucalyptus oil lead to enhanced transdermal absorption of trolamine salicylate through rat skin.

 
Keyword(s): TROLAMINE SALICYLATE, TRANSCUTOL, EUCALYPTUS OIL, TRANSDERMAL ABSORPTION, RAT, NON-LINEAR MIXED EFFECT MODELING
 
 
References: 
  • Not Registered.
  •  
  •  
 
Citations: 
  • Not Registered.
 
+ Click to Cite.
APA: Copy

SAJJADI, P., & KHODAYAR, M., & SHARIF MAKHMALZADEH, B., & REZAEE, S. (2013). PERCUTANEOUS ABSORPTION OF SALICYLIC ACID AFTER ADMINISTRATION OF TROLAMINE SALICYLATE CREAM IN RATS WITH TRANSCUTOL ® AND EUCALYPTUS OIL PRE-TREATED SKIN. ADVANCED PHARMACEUTICAL BULLETIN, 3(2), 295-301. https://www.sid.ir/en/journal/ViewPaper.aspx?id=408882



Vancouver: Copy

SAJJADI PANIZ, KHODAYAR MOHAMMAD JAVAD, SHARIF MAKHMALZADEH BEHZAD, REZAEE SAEED. PERCUTANEOUS ABSORPTION OF SALICYLIC ACID AFTER ADMINISTRATION OF TROLAMINE SALICYLATE CREAM IN RATS WITH TRANSCUTOL ® AND EUCALYPTUS OIL PRE-TREATED SKIN. ADVANCED PHARMACEUTICAL BULLETIN. 2013 [cited 2021October16];3(2):295-301. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=408882



IEEE: Copy

SAJJADI, P., KHODAYAR, M., SHARIF MAKHMALZADEH, B., REZAEE, S., 2013. PERCUTANEOUS ABSORPTION OF SALICYLIC ACID AFTER ADMINISTRATION OF TROLAMINE SALICYLATE CREAM IN RATS WITH TRANSCUTOL ® AND EUCALYPTUS OIL PRE-TREATED SKIN. ADVANCED PHARMACEUTICAL BULLETIN, [online] 3(2), pp.295-301. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=408882.



 
  pdf-File
Yearly Visit 43
 
 
Latest on Blog
Enter SID Blog