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Paper Information

Journal:   ADVANCED PHARMACEUTICAL BULLETIN   2013 , Volume 3 , Number 2; Page(s) 273 To 276.
 
Paper: 

ANTI-INFLAMMATORY EFFECTS OF ZINGIBER OFFICINALE IN TYPE 2 DIABETIC PATIENTS

 
 
Author(s):  MAHLUJI SEPIDE, OSTADRAHIMI ALIREZA*, MOBASSERI MAJID, EBRAHIMZADE ATTARI VAHIDE, PAYAHOO LALEH
 
* TABRIZ UNIVERSITY OF MEDICAL SCIENCES, TABRIZ, IRAN
 
Abstract: 

Purpose: Low-grade inflammation, a common feature in type 2 diabetes (DM2), causes some chronic complications in these patients. The present study was aimed to evaluate the effects of ginger (Zingiber officinale) on pro-inflammatory cytokines (IL-6 and TNF-a) and the acute phase protein hs-CRP in DM2 patients as a randomized double-blind placebo controlled trial.
Methods: A total of 64 DM2 patients randomly were assigned to ginger or placebo groups and received 2 tablets/day of each for 2 months. The concentrations of IL-6, TNF-
a and hs-CRP in blood samples were analyzed before and after the intervention.
Results: Ginger supplementation significantly reduced the levels of TNF-
a (P=0.006), IL-6 (P=0.02) and hs-CRP (P=0.012) in ginger group in comparison to baseline. Moreover, the analysis of covariance showed that the group received ginger supplementation significantly lowered TNF-a (15.3±4.6 vs.19.6±5.2; P=0.005) and hs-CRP (2.42±1.7 vs.2.56±2.18; P=.016) concentrations in comparison to control group. While there were no significant changes in IL-6 (7.9±2.1 vs.7.8±2.9; P>.05).
Conclusion: In conclusion, ginger supplementation in oral administration reduced inflammation in type 2 diabetic patients. So it may be a good remedy to diminish the risk of some chronic complications of diabetes.

 
Keyword(s): GINGER, INFLAMMATION, TNF-α, DIABETES
 
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