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Paper Information

Journal:   ADVANCED PHARMACEUTICAL BULLETIN   2013 , Volume 3 , Number 2; Page(s) 273 To 276.
 
Paper: 

ANTI-INFLAMMATORY EFFECTS OF ZINGIBER OFFICINALE IN TYPE 2 DIABETIC PATIENTS

 
 
Author(s):  MAHLUJI SEPIDE, OSTADRAHIMI ALIREZA*, MOBASSERI MAJID, EBRAHIMZADE ATTARI VAHIDE, PAYAHOO LALEH
 
* TABRIZ UNIVERSITY OF MEDICAL SCIENCES, TABRIZ, IRAN
 
Abstract: 
Purpose: Low-grade inflammation, a common feature in type 2 diabetes (DM2), causes some chronic complications in these patients. The present study was aimed to evaluate the effects of ginger (Zingiber officinale) on pro-inflammatory cytokines (IL-6 and TNF-a) and the acute phase protein hs-CRP in DM2 patients as a randomized double-blind placebo controlled trial.Methods: A total of 64 DM2 patients randomly were assigned to ginger or placebo groups and received 2 tablets/day of each for 2 months. The concentrations of IL-6, TNF-a and hs-CRP in blood samples were analyzed before and after the intervention.Results: Ginger supplementation significantly reduced the levels of TNF-a (P=0.006), IL-6 (P=0.02) and hs-CRP (P=0.012) in ginger group in comparison to baseline. Moreover, the analysis of covariance showed that the group received ginger supplementation significantly lowered TNF-a (15.3±4.6 vs.19.6±5.2; P=0.005) and hs-CRP (2.42±1.7 vs.2.56±2.18; P=.016) concentrations in comparison to control group. While there were no significant changes in IL-6 (7.9±2.1 vs.7.8±2.9; P>.05).Conclusion: In conclusion, ginger supplementation in oral administration reduced inflammation in type 2 diabetic patients. So it may be a good remedy to diminish the risk of some chronic complications of diabetes.
 
Keyword(s): GINGER, INFLAMMATION, TNF-α, DIABETES
 
 
References: 
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Citations: 
 
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APA: Copy

MAHLUJI, S., & OSTADRAHIMI, A., & MOBASSERI, M., & EBRAHIMZADE ATTARI, V., & PAYAHOO, L. (2013). ANTI-INFLAMMATORY EFFECTS OF ZINGIBER OFFICINALE IN TYPE 2 DIABETIC PATIENTS. ADVANCED PHARMACEUTICAL BULLETIN, 3(2), 273-276. https://www.sid.ir/en/journal/ViewPaper.aspx?id=408857



Vancouver: Copy

MAHLUJI SEPIDE, OSTADRAHIMI ALIREZA, MOBASSERI MAJID, EBRAHIMZADE ATTARI VAHIDE, PAYAHOO LALEH. ANTI-INFLAMMATORY EFFECTS OF ZINGIBER OFFICINALE IN TYPE 2 DIABETIC PATIENTS. ADVANCED PHARMACEUTICAL BULLETIN. 2013 [cited 2021December05];3(2):273-276. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=408857



IEEE: Copy

MAHLUJI, S., OSTADRAHIMI, A., MOBASSERI, M., EBRAHIMZADE ATTARI, V., PAYAHOO, L., 2013. ANTI-INFLAMMATORY EFFECTS OF ZINGIBER OFFICINALE IN TYPE 2 DIABETIC PATIENTS. ADVANCED PHARMACEUTICAL BULLETIN, [online] 3(2), pp.273-276. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=408857.



 
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