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Paper Information

Journal:   IRANIAN JOURNAL OF KIDNEY DISEASES (IJKD)   MAY 2014 , Volume 8 , Number 3; Page(s) 201 To 206.
 
Paper: 

LOVASTATIN FOR REDUCTION OF LEPTIN IN NONDIALYSIS PATIENTS WITH TYPE 2 DIABETIC NEPHROPATHY

 
 
Author(s):  GHOLAMIN SHARAREH*, RAZAVI SEYED MOSTAFA, TAGHAVI GARMESTANI SEYED MEGHDAD, GHORBANIHAGHJO AMIR, RASHTCHIZADEH NADEREH, SAFA JAVID, VATANKHAH AMIR MANSOUR, AZIZI TABASSOM, ARGANI HASSAN
 
* INSTITUTE FOR STEM CELL BIOLOGY AND REGENERATIVE MEDICINE, LORRY I. LOKEY STEM CELL RESEARCH BUILDING, STANFORD, CA 94305, USA
 
Abstract: 

Introduction. Diabetic Nephropathy (DN) is one of the main complications of diabetes mellitus, mostly ending to end-stage renal disease. Leptin and C-reactive protein (CRP), as inflammatory markers implicated in the progression of DN, increase in diabetes mellitus, while transferrin and albumin, as members of anti-oxidant defense mechanism, are found to decline.
Materials and Methods. In a controlled clinical trial, 65 patients with type 2 DN were assigned to receive lovastatin or placebo, for 3 months, to assess statins’ impact on serum levels of leptin, CRP, transferrin, albumin, and lipid profile.
Results. Serum levels of CRP (3.52
±4.16 mg/dL to 2.84±3.06 mg/dL, P= .02), leptin (10.78±8.30 mg/dL to 7.80±5.41 mg/dL, P= .006), low-density lipoprotein cholesterol (116.16±46.54 mg/dL to 85.46±29.22 mg/dL, P< .001), and total cholesterol (199.00±43.33 mg/dL to 164.67±35.19 mg/dL, P< .001) were lowered after lovastatin therapy. Mean serum level of high-density lipoprotein cholesterol increased (40.00 mg/dL to 42.80 mg/dL, P= .005) after the treatment. Lovastatin had no significant effect on albumin and transferrin. Placebo did not change any of the parameters after 3 months.
Conclusions. The effect of statins on the inflammatory markers involved in the development of DN is a new approach to evidence supporting the pleiotropic effect of this drug group.

 
Keyword(s): LOVASTATIN, LEPTIN, TRANSFERRIN, ALBUMIN, DIABETIC NEPHROPATHY
 
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