Paper Information

Journal:   IRANIAN JOURNAL OF KIDNEY DISEASES (IJKD)   MAY 2014 , Volume 8 , Number 3; Page(s) 194 To 200.
 
Paper: 

REGULATORY EFFECTS OF CHRONIC LOW-DOSE MORPHINE ON NITRIC OXIDE LEVEL ALONG WITH BAROREFLEX SENSITIVITY IN TWO-KIDNEY ONE-CLIP HYPERTENSIVE RATS

 
 
Author(s):  REZAZADEH HOSSEIN, HOSSEINI KAHNOUEI MOHAMMADAMIN, HASSANSHAHI GHOLAMHOSSEIN, ALLAHTAVAKOLI MOHAMMAD, SHAMSIZADEH ALI, ROOHBAKHSH ALI, FATEMI IMAN, ZARISFI MOHAMMAD REZA, POURSHANAZARI ALI ASGHAR*
 
* PHYSIOLOGY-PHARMACOLOGY RESEARCH CENTER, RAFSANJAN UNIVERSITY OF MEDICAL SCIENCE, RAFSANJAN, IRAN
 
Abstract: 

Introduction. Opiates are traditionally used for treatment of some acute heart disorders. There are only few reports on the effects of long-term treatment of cardiovascular diseases with morphine. This study aimed to investigate the effects of chronic low-dose morphine use on the cardiovascular system in two-kidney one-clip (2K1C) hypertensive rats.
Materials and Methods. Male Wistar rats were divided into two groups as the sham and 2K1C groups and each group was further subdivided into saline and morphine treatment subgroups. Blood pressure, heart rate, plasma rennin activity, serum nitric oxide concentration, and baroreflex sensitivity were measured.
Results. Morphine significantly attenuated systolic blood pressure, diastolic blood pressure, and mean arterial pressure in the 2K1C animals. In addition, morphine decreased plasma rennin activity in the 2K1C group. Serum concentrations of nitric oxide were also decreased, and morphine prevented the reduction of nitric oxide. The baroreflex sensitivity was also improved following morphine administration in the 2K1C group.
Conclusions. According to the results presented in this study, chronic administration of low-dose morphine reduces regulated hypertension in the 2K1C rats, probably via a nitric oxide-dependent pathway.

 
Keyword(s): BAROREFLEX SENSITIVITY, MORPHINE, NITRIC OXIDE, RENNIN ACTIVITY, RATS
 
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