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Paper Information

Journal:   BASIC AND CLINICAL NEUROSCIENCE   SPRING 2014 , Volume 5 , Number 2; Page(s) 162 To 168.
 
Paper: 

EFFECTS OF HYDROALCOHOLIC EXTRACT OF TANACETUM SONBOLII (ASTERACEAE) ON PAIN-RELATED BEHAVIORS DURING FORMALIN TEST IN MICE

 
 
Author(s):  SOFIABADI MOHAMMAD, AZHDARI ZARMEHRI HASSAN*, NADERI FIROUZEH, GHALANDARI SHAMAMI MOHADESEH, SONBOLI ALI, HAGHPARAST ABBAS
 
* DEPARTMENT OF BASIC SCIENCES, TORBAT HEYDARIYEH UNIVERSITY OF MEDICAL SCIENCES, TORBAT HEYDARIYEH, IRAN
 
Abstract: 

Introduction: Tanacetum sonbolii (Asteraceae) is an endemic species in Iran. In the present study, we examined the effects of Tanacetum sonbolii hydroalcoholic extract on the formalin test in mice.
Methods: 126 Swiss albino mice weighing 230-280g were used as subjects. The formalin test was performed on two control groups (marked as intact and saline groups; n=6 in each group) and an experimental group. In all groups, the formalin test was recorded for 60 min after administration of extract and drugs in mice.
Results: The results showed that Tanacetum sonbolii (150 and 300 mg/kg) produced significant antinociception in phase 2. In addition, different doses of Tanacetum sonbolii extract (600, 900 and 1200 mg/kg) also induced antinociceptive effects in phase1 and phase 2. On the other hand, morphine could induce antinociception in a dose-dependent manner. Diclofenac (10 mg/ kg) failed to affect the pain scores compared to Tanacetum sonbolii (300 mg/kg) group.
Discussion: It seems that administration of hydroalcoholic extract of Tanacetum sonbolii has the potential to relieve pain through both central and peripheral mechanisms in persistent inflammatory nociception.

 
Keyword(s): TANACETUM SONBOLII (ASTERACEAE), MORPHINE, FORMALIN TEST, MICE
 
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